1008个冷冻胚胎移植周期妊娠结局影响因素的分析

发布时间：2018-01-30 00:23

本文关键词： 冷冻胚胎移植临床妊娠影响因素　出处：《中国性科学》2016年03期 　论文类型：期刊论文

【摘要】：目的:探讨影响卵裂期冷冻胚胎移植妊娠结局的相关因素。方法:回顾性分析2011年1月至2014年12月在北京大学第一医院进行卵裂期冻胚移植的1008个周期,探讨患者年龄、不孕年限、不孕类型、内膜准备方式、内膜厚度及类型、受精方式、胚胎冷冻方法、辅助孵化、胚龄、移植胚胎数量及质量等对冷冻胚胎移植妊娠结局的影响。结果:1008个胚胎解冻周期,复苏胚胎2883个,存活2503个(86.8%),完成冻胚移植周期981个(97.3%),临床妊娠周期413个(42.9%),胚胎种植率23.6%,早期流产率14.0%。年轻患者、全胚冷冻后第一次冻胚移植、选择玻璃化冷冻方法、移植≥2枚胚胎尤其是≥2枚优质胚胎的冷冻胚胎移植妊娠率较高。结论:在诸多因素中,年龄、冷冻方法、是否全胚胎冷冻、移植胚胎数目及质量对冻胚移植妊娠结局影响显著。
[Abstract]:Objective: to investigate the related factors influencing the pregnancy outcome of cryopreservation embryo transfer in cleavage stage. From January 2011 to December 2014, 1008 cycles of cryogenic embryo transplantation in the cleavage stage were analyzed in the first Hospital of Peking University. To investigate the age, length of infertility, type of infertility, preparation of endometrium, thickness and type of intima, fertilization, embryo freezing, assisted hatching and embryo age. Effects of quantity and quality of transferred embryos on pregnancy outcome of frozen embryo transfer. Results: 1 008 embryos were thawed, 2883 embryos were resuscitated, and 2503 embryos survived (86.8%). 981 embryo transfer cycles were completed, 413 clinical pregnancy cycles were 42.9, embryo implantation rate was 23.6m, early abortion rate was 14.00.Young patients. For the first frozen embryo transfer after whole embryo freezing, vitrification method was chosen to transfer more than 2 embryos, especially more than 2 high quality embryos. Conclusion: in many factors, age is the most important factor. Freezing method, whether the whole embryo is frozen or not, the number and quality of transferred embryos have significant influence on the pregnancy outcome of frozen embryo transfer.
【作者单位】：北京大学第一医院妇产科;北京大学第一医院泌尿外科;
【分类号】：R714.8
【正文快照】： 自Trouson等1983年获得世界首例冷冻胚胎移植(frozen-thawed embryo transfer,FET)临床妊娠成功[1],冻融胚胎移植技术成为辅助生殖技术的重要组成部分。冷冻胚胎移植不仅能提高单取卵周期的累计妊娠率,减少中、重度卵巢过度刺激综合征(ovarian hyperstimulation syndrome,OHSS

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