GnRH-a联合LNG-IUS治疗大子宫腺肌病和子宫肌瘤的近期临床疗效观察

发布时间：2018-01-30 00:03

本文关键词： 子宫腺肌病子宫肌瘤 GnRH-a LNG-IUS 近期疗效　出处：《中外女性健康研究》2016年14期 　论文类型：期刊论文

【摘要】：目的:评价GnRH-a联合LNG-IUS治疗大子宫腺肌病和子宫肌瘤的近期临床疗效与安全性。方法:2013年1月至2014年1月,医院共以GnRH-a联合LNG-IUS治疗大子宫腺肌病和子宫肌瘤40例。结果:GnRH-a注射3~5次,平均(3.4±0.4)次,平均注射(1.8±0.5)支出现闭经;患者随访时间10~12个月,患者痛经评分、PBAC逐渐下降,子宫大小呈先下降、后上升、再下降趋势,在放置LNG-IUS第6个月达到拐点,肌瘤呈现先下降后持续上升趋势,在放置LNG-IUS后肌瘤体积持续上升,差异具有统计学意义(P0.05);GnRH-a注射不良反应发生率为42.5%,不良反应例次率为82.5%,LNG-IUS不良反应发生率为72.5%,不良反应例次率为100.0%。结论:GnRH-a联合LNG-IUS治疗大子宫腺肌病和子宫肌瘤的近期临床疗效较好,但其不能预防肌瘤复发,且不良反应发生率偏高。
[Abstract]:Objective: to evaluate the efficacy and safety of GnRH-a combined with LNG-IUS in the treatment of large uterine adenomyosis and uterine leiomyoma. Methods: from January 2013 to January 2014. 40 cases of adenomyosis and hysteromyoma were treated with GnRH-a and LNG-IUS. Results 5 times of injection of 1% GnRH-a were given, with an average of 3.4 卤0.4 times. Amenorrhea occurred in the mean injection of 1.8 卤0.5) branches. The patients were followed up for 10 ~ 12 months. The score of dysmenorrhea decreased gradually, and the uterine size decreased first, then increased, then decreased, and reached the inflection point at the 6th month after placing LNG-IUS. The volume of leiomyoma increased after LNG-IUS was placed, and the difference was statistically significant (P 0.05). The adverse reaction rate of GnRH-a injection was 42.5 and the adverse reaction rate was 82.5%. The adverse reaction rate of LNG-IUS was 72.5%. The adverse reaction rate was 100.00.Conclusion the short-term clinical effect of LNG-IUS combined with GnRH-a in the treatment of large uterine adenomyosis and uterine leiomyoma is better, but it can not prevent the recurrence of myoma. The incidence of adverse reactions was high.
【作者单位】：河南省新郑市妇幼保健院妇产科;
【分类号】：R711.71;R737.33
【正文快照】： 子宫腺肌病、子宫肌瘤均为临床常见妇科疾病,我国子宫腺肌病发病率为10%~18%,子宫肌瘤发病率为30%~60%[1]。LNG-IUS即左旋-19甲基炔诺酮,是一种缩小宫体药物,配合宫内缓释系统适用于经过长期治疗、子宫因疾病明显增大患者,可预防复发,控制症状,但目前相关研究仍较少。2013年1

【相似文献】