自然周期卵泡发育及是否排卵对解冻周期妊娠结局的影响

发布时间：2018-01-30 17:12

本文关键词： 卵泡发育排卵解冻移植自然周期卵裂期胚胎囊胚期胚胎　出处：《实用妇产科杂志》2015年12期 　论文类型：期刊论文

【摘要】：目的:探讨自然周期冻融胚胎移植(FET)影响助孕结局的有关因素。方法:回顾性分析2012年1月至2013年12月就诊于郑州大学第一附属医院生殖中心,采用自然周期行FET共1493例(1493周期)的临床资料,根据卵泡发育情况(以卵泡直径16.0 mm为界值)分为大卵泡组和小卵泡组,根据是否排卵分为排卵组和未排卵组。比较各组在LH峰日雌二醇(E_2)、孕酮(P)水平及其妊娠结局,以及移植卵裂期或囊胚期胚胎时不同分组的妊娠率和活产率。结果:1LH峰日小卵泡组的血清E_2值低于大卵泡组(P0.01),而孕酮(P)值差异无统计学意义(P0.05);卵泡排卵组与未排卵组E_2及P值的差异均无统计学意义(P0.05)。2大小卵泡组的临床妊娠率及活产率比较,差异均无统计学意义(P0.05);卵泡排卵组临床妊娠率及活产率均高于未排卵组(P0.05)。3移植卵裂期胚胎排卵组的临床妊娠率及活产率均高于未排卵组(P0.05);而移植囊胚期胚胎排卵组与未排卵组的临床妊娠率及活产率比较,差异均无统计学意义(P0.05)。结论:自然周期FET时,内膜转化日卵泡大小对妊娠及产科结局无影响。卵泡排卵对妊娠结局有利,卵泡未排卵选择移植囊胚期胚胎可能有利于提高成功率。
[Abstract]:Objective: to study the natural cycle frozen-thawed embryo transfer (fet). Methods: from January 2012 to December 2013, a retrospective analysis was conducted at the Reproductive Center of the first affiliated Hospital of Zhengzhou University. The clinical data of 1 493 cases (1 493 cycles of FET) were divided into large follicle group and small follicle group according to follicular development (16. 0 mm follicle diameter as the cutoff). Each group was divided into ovulation group and non-ovulation group according to whether ovulation was ovulation. The levels of estradiol estradiol E _ (2) and progesterone (P) and pregnancy outcome were compared in each group on the day of LH peak. The pregnancy rate and live delivery rate of different groups during embryo transplantation at cleavage stage or blastocyst stage. Results the serum E2 value of follicle group was lower than that of large follicle group (P 0.01). However, there was no significant difference in the value of progesterone (P0. 05). There was no significant difference in E _ 2 and P values between follicular ovulation group and non-ovulation group. There was no significant difference in clinical pregnancy rate and live birth rate between follicular size group and non-ovulatory group. There was no significant difference in E _ 2 and P value between follicular ovulation group and non-ovulatory group. The clinical pregnancy rate and live delivery rate of follicular ovulation group were higher than that of non-ovulation group (P 0.05.3). However, there was no significant difference in clinical pregnancy rate and live delivery rate between ovulatory group and non-ovulation group in blastocyst stage. Conclusion: during natural cycle FET, there is no significant difference in clinical pregnancy rate and live delivery rate. Follicle size had no effect on pregnancy and obstetrical outcome on the day of endometrial transformation. Follicular ovulation was beneficial to pregnancy outcome, and follicular unovulation selection of blastocyst stage embryo might help to improve the success rate.
【作者单位】：郑州大学第一附属医院;
【分类号】：R714.8
【正文快照】： 冻融胚胎移植(frozen embryos transfer,FET)助孕时内膜准备有多种方案,包括自然周期、激素替代周期、降调节周期等,其中,自然周期因花费少、符合胚胎着床的生理要求、更接近自然受孕状态而成为最常见的子宫内膜准备方案之一。在自然周期方案行FET时,卵泡的监测过程非常重要,

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