新鲜周期与复苏周期囊胚移植效果的历史性队列研究

发布时间：2018-01-31 04:47

本文关键词： 队列研究胚胎移植囊胚新鲜冻融妊娠结局　出处：《第二军医大学学报》2017年07期 　论文类型：期刊论文

【摘要】：目的比较新鲜周期和复苏周期囊胚移植的相关参数及其临床结局。方法采用历史性队列研究方法,将2015年3月—2016年12月在第二军医大学长海医院生殖医学中心接受助孕治疗的患者分为新鲜周期囊胚移植组(61例)和复苏周期囊胚移植组(372例),收集其临床结局资料,比较两组患者的囊胚种植率和临床妊娠率。根据移植天数将复苏周期囊胚移植组分为第5天组(n=308)和第6天组(n=64)2个亚组,分析其临床结局的差异。结果新鲜周期和复苏周期囊胚移植组患者的年龄和移植囊胚数差异均无统计学意义,复苏周期囊胚移植组患者的囊胚种植率高于新鲜周期囊胚移植组(40.2%vs 29.6%,P=0.036),但两组患者的临床妊娠率差异无统计学意义(57.8%vs 47.5%,P=0.134)。复苏周期囊胚移植第5天组患者的囊胚种植率和临床妊娠率均高于第6天组(囊胚种植率42.3%vs 30.1%,P=0.016;临床妊娠率60.7%vs 43.8%,P=0.012)。结论复苏周期囊胚移植可比新鲜周期囊胚移植获得更好的妊娠结局,且第5天移植者比第6天移植者效果更佳。
[Abstract]:Objective to compare the relevant parameters and clinical outcome of blastocyst transplantation in fresh cycle and resuscitation cycle. Methods A historical cohort study was used. From March 2015 to December 2016, the patients receiving assisted pregnancy therapy at the Center of Reproductive Medicine, Changhai Hospital, second military Medical University, were divided into two groups: fresh cycle blastocyst transplantation group (61 cases) and resuscitation cycle blastocyst transplantation group (. (372 cases). The clinical outcome data were collected. The blastocyst implantation rate and clinical pregnancy rate of the two groups were compared. According to the days of transplantation, the blastocyst transplantation components of the resuscitation cycle were divided into two subgroups: the 5th day group (n = 308) and the 6th day group (n = 64). Results there was no significant difference in age and number of blastocysts in fresh and resuscitation cycles. The blastocyst implantation rate in the resuscitation cycle blastocyst group was higher than that in the fresh cycle blastocyst transplantation group (40.2 vs 29.6P0. 036). However, there was no significant difference in clinical pregnancy rate between the two groups (57.8 vs 47.5%). The blastocyst implantation rate and clinical pregnancy rate in the 5th day group of the resuscitation cycle were higher than those in the 6th day group (42.3% vs 30.1%). The clinical pregnancy rate was 60.7% vs 43.8%. Conclusion the resuscitation cycle blastocyst transplantation is better than the fresh cycle blastocyst transplantation. And the 5th day transplant was better than the 6 th day transplant.
【作者单位】：第二军医大学长海医院生殖医学中心;南京医科大学流行病学系;中国科学院遗传与发育生物学研究所;
【分类号】：R714.8
【正文快照】： 随着辅助生育技术的发展和胚胎培养系统的改良,囊胚培养和移植得到越来越广泛的应用。囊胚培养既能筛选出更具发育潜能的胚胎,又能使胚胎与子宫内膜更为同步,移植后可获得较高的囊胚种植率和良好的妊娠结局。但是目前有关囊胚移植的策略仍存在一定的争议[1],如是行新鲜周期直

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