G蛋白偶联雌激素受体和Gankyrin蛋白在卵巢子宫内膜异位症中的表达及意义

发布时间：2018-02-02 08:40

本文关键词： 卵巢子宫内膜异位症 G蛋白偶联雌激素受体 Gankyrin 雌激素　出处：《中南大学学报(医学版)》2015年08期 　论文类型：期刊论文

【摘要】：目的:研究新型雌激素受体G蛋白偶联雌激素受体(G protein-coupled estrogen receptor,GPER)和Gankyrin在卵巢子宫内膜异位症中的表达及其临床病理意义,探讨二者在卵巢子宫内膜异位症发生、发展中的作用。方法:采用免疫组织化学法检测GRER和Gankyrin蛋白在卵巢子宫内膜异位症患者的异位内膜、在位内膜及正常子宫内膜中的表达情况及定位分布,结合临床资料分析其与卵巢子宫内膜异位症分期的关系,并评估两者之间的相关性。结果:GPER蛋白在异位、在位及正常内膜中的阳性表达率分别为63.6%,51.5%,21.2%,异位及在位内膜组的阳性表达显著高于正常内膜组(均P0.0125),而异位与在位内膜间差异无统计学意义(P0.0125);Gankyrin蛋白在异位、在位及正常内膜中的阳性表达率分别为69.7%,36.4%,9.1%,组间两两比较差异均有统计学意义(均P0.0125)。在位内膜中,GPER蛋白表达在增生期高于分泌期(P0.05),Gankyrin蛋白在增生期与分泌期的表达差异无统计学意义(P0.05)。GPER和Gankyrin蛋白的表达与卵巢子宫内膜异位症的临床分期有关,二者在III~IV期的阳性表达率高于I~II期(均P0.05)。GPER和Gankyrin蛋白在异位内膜中的表达呈正相关(rs=0.640,P0.01)。结论:GPER和Gankyrin的表达与卵巢子宫内膜异位症的发生、发展及临床分期有关,二者可能通过相互作用促进异位病灶的形成。
[Abstract]:Objective: to study a novel estrogen receptor G protein coupled estrogen receptor G protein-coupled estrogen receptor. The expression and clinicopathological significance of GPERand Gankyrin in ovarian endometriosis were studied. Methods: immunohistochemical method was used to detect the expression of GRER and Gankyrin protein in the endometriosis of ovarian endometriosis. The expression and localization of eutopic endometrium and normal endometrium were analyzed in combination with clinical data. Results the positive expression rates of GPER protein in ectopic, eutopic and normal endometrium were 63.6% and 51.5%, respectively. The positive expression in ectopic and eutopic endometrium was significantly higher than that in normal endometrium (P0.0125), but there was no significant difference between ectopic and eutopic endometrium. The positive expression rates of Gankyrin protein in ectopic, eutopic and normal endometrium were 69.7% and 36.4%, respectively. The expression of GPER in eutopic endometrium was higher in proliferative phase than in secretory phase (P0.05). There was no significant difference in the expression of Gankyrin protein between proliferative phase and secretory phase (P0.05). The expression of GPER and Gankyrin protein was related to the clinical stage of ovarian endometriosis. The positive expression rate of GPER and Gankyrin protein in the III~IV phase was higher than that in the II stage (both P0.05N. GPER and Gankyrin protein expression in ectopic endometrium were positively correlated with the expression of rst0. 640). Conclusion the expression of GPER and Gankyrin is related to the occurrence, development and clinical stage of ovarian endometriosis, which may promote the formation of ectopic lesions through interaction.
【作者单位】：中南大学湘雅医院妇产科;
【分类号】：R711.71
【正文快照】： 子宫内膜异位症(endometriosis,EMT)是指具有生长活性的子宫内膜组织(包括腺体和间质)出现在子宫腔以外的部位并定植生长的异质性疾病。异位内膜可侵犯全身任何部位,但以卵巢最为常见。EMT发病率10%~15%,主要表现为明显的痛经、慢性盆腔痛及不孕,严重影响女性的生活质量及身心

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