多囊卵巢综合征患者血清维生素D水平与肥胖、胰岛素抵抗的相关性分析

发布时间：2018-02-04 15:21

本文关键词： 多囊卵巢综合征维生素D 肥胖胰岛素抵抗　出处：《安徽医药》2016年02期 　论文类型：期刊论文

【摘要】：目的探讨多囊卵巢综合征患者(PCOS)血清维生素D水平与肥胖、胰岛素抵抗的相关性分析。方法选择2013年12月—2015年3月该院妇产科就诊的118例PCOS为研究对象(PCOS组),选择同期进行健康体检、月经正常的80例育龄期妇女为对照组,比较两组患者的血清25-(OH)D水平、肥胖相关指标(BMI、腰围/臀围比值、瘦素)、胰岛素抵抗相关指标(胰岛素、HOMA-IR、HOMA-β、QUICKI),分析血清25-(OH)D水平与肥胖相关指标和胰岛素抵抗相关指标的相关性。结果PCOS组血清25-(OH)D的水平和QUICKI指数均明显低于对照组,而PCOS组中BMI指数、腰围/臀围比值、瘦素水平、胰岛素水平、HOMA-IR和HOMA-β均高于对照组,差异均具有统计学意义(P0.05)。不同体质量指数的PCOS组25-(OH)D水平和QUICKI指数均低于对照组,胰岛素水平、HOMA-IR和HOMA-β均高于对照组,差异均具有统计学意义(P0.05)。PCOS组中胰岛素抵抗患者25-(OH)D水平低于非胰岛素抵抗患者,BMI指数、腰围/臀围比值、瘦素水平均高于非胰岛素抵抗患者(P0.05)。相关性的分析结果显示,血清维生素D水平与QUICKI指数呈明显正相关,而与BMI指数、腰围/臀围比值、瘦素水平、胰岛素水平、HOMA-IR和HOMA-β均呈明显的负相关。结论 PCOS血清维生素D水平与肥胖和胰岛素抵抗均呈明显的负相关,三者与PCOS的发生密切相关。
[Abstract]:Objective to investigate the relationship between serum vitamin D level and obesity in patients with polycystic ovary syndrome (PCOS). Methods from December 2013 to March 2015, 118 cases of PCOS in gynecology and obstetrics department of our hospital were selected as the study object. 80 healthy women with normal menstruation were selected as the control group. The serum levels of 25-OHH D, BMIs and waistline / hip circumference ratio were compared between the two groups. Leptin, insulin resistance-related index (HOMA-IRN HOMA- 尾 -QUICKI). To analyze the correlation between the serum levels of 25-OHH and obesity and insulin resistance. Results the serum levels of 25-OHH in the PCOS group were compared with those in the control group (P < 0.05). The level of D and QUICKI index were significantly lower than those of the control group. The BMI index, waist circumference / hip circumference ratio, leptin level, insulin level, HOMA-IR and HOMA- 尾 in PCOS group were higher than those in control group. The difference was statistically significant (P 0.05). The levels of OHH D and QUICKI in PCOS group with different BMI were lower than those in control group and insulin level. HOMA-IR and HOMA- 尾 were higher than those of control group. The difference was statistically significant (P 0.05). The level of OHH D in insulin resistance patients was lower than that in non-insulin resistance patients (BMI, waist circumference / hip circumference ratio). The levels of leptin were higher than those of non-insulin resistance patients (P 0.05). The results of correlation analysis showed that the serum vitamin D level was positively correlated with QUICKI index and BMI index. Waist / hip ratio, leptin level, insulin level. Conclusion the serum vitamin D level of PCOS is negatively correlated with obesity and insulin resistance. They are closely related to the occurrence of PCOS.
【作者单位】：武汉市汉阳医院内分泌科;
【分类号】：R711.75
【正文快照】： 多囊卵巢综合征(polycystic ovary syndrome,P-COS)是导致女性不育的一个常见原因,育龄妇女的患病率为5%~10%,其临床表现包括月经不规则,多毛,痤疮,不孕不育和脱发[1-2]。目前的报道认为,PCOS的发生是由复杂的下丘脑—垂体—卵巢或下丘脑—垂体—肾上腺轴功能与代谢性疾病的相

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