宫颈鳞癌中CXCR4的表达变化与宫颈鳞癌细胞侵袭性关系

发布时间：2018-02-07 17:59

  本文关键词： 宫颈鳞癌 趋化因子受体 细胞侵袭性　出处：《现代预防医学》2015年13期 　论文类型：期刊论文

【摘要】：目的检测宫颈癌患者鳞癌组织中CXCR4的表达,观察其与宫颈鳞癌各种临床病理参数的关系,从而为探讨CXCR4与宫颈癌侵袭性的机制研究提供一定的实验依据。方法收集我院妇产科收治的145例宫颈癌手术治疗患者临床病理资料及切除标本,采用免疫组织化学SP法检测标本中CXCR4的表达情况,并通过Transwell实验了解CXCR4过表达的细胞迁移情况。结果不同FIGO病理分期、不同组织分化程度及不同淋巴结转移情况的患者之间,CXCR4表达的阳性率差异有统计学意义(P0.05),FIGO分期为Ⅱ期及Ⅲ期者阳性率较高,组织分化程度越低者阳性率越高,发生淋巴结转移者CXCR4表达的阳性率高于未转移者。宫颈鳞癌细胞迁移实验结果显示,除CXCR4过表达3 h和6 h两个时点外,其余各时间点宫颈鳞癌细胞过表达CXCR4组与对照组相比较,平均迁移细胞数的差异均具有统计学意义(P0.05)。结论宫颈鳞癌组织中CXCR4高表达可能在宫颈鳞癌的侵袭、转移中起重要作用,对细胞侵袭和转移能力有促进作用。
[Abstract]:Objective to detect the expression of CXCR4 in squamous cell carcinoma (SCC) of cervical cancer, and to observe the relationship between the expression of CXCR4 and the clinicopathological parameters of cervical squamous cell carcinoma (SCC). Methods the clinical and pathological data and excision specimens of 145 patients with cervical cancer treated by surgical treatment in gynecology and obstetrics department in our hospital were collected. Immunohistochemical SP method was used to detect the expression of CXCR4 in the specimens, and the cell migration of CXCR4 overexpression was studied by Transwell assay. Results the pathological stages of FIGO were different. The positive rate of CXCR4 expression in patients with different tissue differentiation degree and different lymph node metastasis was significantly different. The positive rate of stage 鈪，

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