455例闭经患者细胞遗传学分析

发布时间：2018-02-10 00:15

本文关键词： 闭经染色体核型遗传学分析性腺发育不良先天畸形　出处：《中国妇产科临床杂志》2015年04期 　论文类型：期刊论文

【摘要】：目的探讨外周血细胞染色体检查在闭经患者诊断中的临床意义。方法回顾性分析1990年1月至2013年1月山西医科大学第一临床医院进行外周血淋巴细胞染色体检查的455例闭经患者的临床资料,并分为原发性闭经组与继发性闭经组,比较两组患者染色体检查结果及临床特点。结果在455例患者中,染色体异常104例(22.86%),其中原发性闭经患者染色体异常率为24.59%(89/362);继发性闭经患者为16.13%(15/93)。原发性闭经组中先天性无子宫和(或)无阴道患者156例,其中染色体正常124例,异常32例。原发性闭经合并内分泌异常者占20.17%(73/362),继发性闭经合并内分泌异常占68.82%(64/93)。104例染色体异常患者中,含Y染色体者占30.77%(32/104),X染色体数目异常占46.15%(48/104),X染色体结构异常占19.23%(20/104),常染色体异常占3.85%(4/104)。结论染色体异常是导致闭经的主要原因,不仅重视原发闭经患者的染色体检查,继发闭经患者也不容忽视。
[Abstract]:Objective to investigate the clinical significance of peripheral blood cell chromosome examination in the diagnosis of amenorrhea. Methods from January 1990 to January 2013, the chromosome examination of peripheral blood lymphocytes was performed in the first Clinical Hospital of Shanxi Medical University. Clinical data of 455 patients with amenorrhea, It was divided into primary amenorrhea group and secondary amenorrhea group. The results of chromosome examination and clinical features were compared between the two groups. There were 104 cases of chromosomal abnormalities, of which the rate of chromosomal abnormalities in primary amenorrhea was 24.5989 / 362g; in secondary amenorrhea, 16.131315 / 93%; in primary amenorrhea, 156 cases were congenital without uterus and / or without vagina, among which 124 cases were normal chromosomes. 32 cases were abnormal. Primary amenorrhea complicated with endocrine abnormality accounted for 20.1773 / 362a, secondary amenorrhea with endocrine abnormality accounted for 68.82n64 / 93n.104 cases with chromosomal abnormality. The number of chromosomes with Y chromosomes is 30.7777 / 104% and the number of X chromosomes is abnormal, accounting for 46.15% and 46.15%. The chromosomal structural abnormalities of 48% 104% X chromosomes account for 19.23% 10 / 104%, and the autosomal abnormalities account for 3.85% 104% .Conclusion chromosomal abnormalities are the main cause of amenorrhea, and not only the chromosome examination of primary amenorrhea patients, Secondary amenorrhea patients should not be ignored.
【作者单位】：山西医科大学第一临床医学院妇产科;山西大医院妇产科;山西医科大学第一医院;
【分类号】：R711.51

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