p65在原发性上皮性卵巢癌中的表达及其临床意义

发布时间：2018-02-11 08:56

本文关键词： 卵巢肿瘤 p 病理学　出处：《实用医学杂志》2017年03期 　论文类型：期刊论文

【摘要】：目的:探讨p65在原发性上皮性卵巢癌的表达及临床意义。方法:选择我院2010年1月至2015年12月收治的70例原发性上皮性卵巢癌患者、10例交界恶性上皮性卵巢肿瘤患者及15例健康体检者,采用免疫组织化学SP法对3组卵巢组织中p65的表达进行检测,分析其表达与上皮性卵巢癌的发生、发展的关系。结果:p65在正常卵巢组织、原发性上皮性卵巢癌及交界恶性卵巢肿瘤中阳性表达主要位于细胞核;原发性上皮性卵巢癌临床分期和分化程度越高,p65阳性表达率越高;p65在正常卵巢组织、原发性上皮性卵巢癌及交界恶性卵巢肿瘤中的阳性表达率比较差异有显著性(P0.05)。结论:p65与原发性上皮性卵巢癌的发生有关,p65的高表达提示预后不良。
[Abstract]:Objective: to investigate the expression of p65 in primary epithelial ovarian carcinoma and its clinical significance. Methods: from January 2010 to December 2015, 70 patients with primary epithelial ovarian cancer were treated in our hospital. 10 cases of borderline malignant epithelial ovarian tumor were selected. Patients and 15 healthy persons, Immunohistochemical SP method was used to detect the expression of p65 in three groups of ovarian tissues, and the relationship between the expression of p65 and the occurrence and development of epithelial ovarian carcinoma was analyzed. The positive expression of p65 in primary epithelial ovarian carcinoma and borderline malignant ovarian tumor was mainly located in the nucleus, and the higher the clinical stage and differentiation of primary epithelial ovarian carcinoma was, the higher the positive expression rate of p65 was in normal ovarian tissues. There was a significant difference in the positive expression rate between primary epithelial ovarian carcinoma and borderline malignant ovarian tumor (P0.050.Conclusion the high expression of p65 is associated with the occurrence of primary epithelial ovarian cancer, suggesting poor prognosis.
【作者单位】：广东省汕尾市人民医院妇产科;
【基金】：广东省医学科学技术研究基金项目(编号:A2016282)
【分类号】：R737.31

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