miR-145和IL-10在子宫内膜样腺癌的表达及其相关性

发布时间：2018-02-11 18:10

本文关键词： 子宫内膜样腺癌微小RNA- 白细胞介素-　出处：《免疫学杂志》2017年01期 　论文类型：期刊论文

【摘要】：目的分析微小RNA-145(miR-145)和白细胞介素-10(IL-10)在子宫内膜样腺癌中的表达及两者表达的相关性。方法收集65例子宫内膜样腺癌手术患者的组织标本作为实验组,其中高分化患者21例,中分化患者27例,低分化患者17例。取同期在门诊刮宫经病理证实为子宫内膜单纯性增生的患者23例作为对照组。采用实时荧光定量PCR法技术检测miR-145和IL-10 m RNA在2组患者中的表达水平。结果 miR-145在子宫内膜样腺癌患者中的表达水平低于对照组,随着分化程度的降低而降低;IL-10在子宫内膜样腺癌患者中的表达水平明显高于对照组,随着分化程度的降低而升高;miR-145与IL-10之间呈负相关;差异均具有统计学意义。结论 miR-145在子宫内膜样腺癌患者中表达下降,IL-10在子宫内膜样腺癌患者中表达升高,且两者呈负相关。
[Abstract]:Objective to analyze the expression of minimal RNA-145 miR-145) and interleukin-10 (IL-10) in endometrial adenocarcinoma and their correlation. Methods the tissue specimens of 65 patients with endometrioid adenocarcinoma were collected as experimental group, including 21 well-differentiated patients. There were 27 cases of moderately differentiated patients, The expression of miR-145 and IL-10 m RNA were detected by real-time fluorescence quantitative PCR technique in 23 patients with endometrial simple hyperplasia confirmed pathologically by curettage in outpatient clinic. Results the expression of miR-145 in endometrioid adenocarcinoma patients was lower than that in control group. The expression of IL-10 in endometrioid adenocarcinoma patients was significantly higher than that in the control group with the decrease of differentiation degree, and the expression of IL-10 in endometrioid adenocarcinoma patients was negatively correlated with the decrease of differentiation degree. Conclusion the expression of IL-10 in patients with endometrial adenocarcinoma is significantly higher than that in patients with endometrial adenocarcinoma, and there is a negative correlation between the expression of IL-10 and IL-10 in endometrioid adenocarcinoma.
【作者单位】：青岛大学附属医院妇科;德州市人民医院产科;
【分类号】：R737.33

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