P27和Stathmin在宫颈癌组织中的表达及其相互关系

发布时间：2018-02-13 11:27

本文关键词： Stathmin P CIN 宫颈癌免疫组化　出处：《中国现代医生》2016年29期 　论文类型：期刊论文

【摘要】：目的探讨宫颈癌组织中P27蛋白和Stathmin蛋白的表达及其相互关系。方法应用免疫组织化学方法检测P27蛋白和Stathmin蛋白在40例正常宫颈组织、40例宫颈上皮内瘤变(Cervical Intraepithelial Neoplasia,CIN)组织和60例宫颈癌组织中的表达水平。结果 P27蛋白在正常宫颈组织、CIN组织和宫颈癌组织中阳性表达率分别为87.5%、77.5%和50.0%,三组之间差异有统计学意义(χ~2=17.732,P0.05),Stathmin蛋白在正常宫颈组织、CIN组织和宫颈癌组织中阳性表达率分别为17.5%、52.5%和86.7%,三组之间差异有统计学意义(χ~2=67.1,P0.05)。P27和Stathmin蛋白表达与患者的年龄无关(P0.05),P27和Stathmin蛋白的表达与宫颈癌的组织学分化程度、有无淋巴结转移和临床分期有明显的相关性(P0.05)。宫颈癌中Stathmin蛋白表达与P27蛋白表达呈负相关(r=-1,P0.05)。结论 P27蛋白和Stathmin蛋白检测可作为宫颈癌诊断中的一组肿瘤标记物,Stathmin蛋白可通过抑制P27蛋白的表达,促进宫颈癌的发生发展。
[Abstract]:Objective to investigate the expression of P27 protein and Stathmin protein and their relationship in cervical carcinoma. Methods Immunohistochemical method was used to detect the expression of P27 protein and Stathmin protein in 40 normal cervical tissues and 40 cases of cervical intraepithelial neoplasia (Cervical Intraepithelial Neoplasia cin). Results the positive expression rates of P27 protein in cin and cervical cancer tissues were 87.57.5% and 50.0%, respectively. There was significant difference among the three groups (蠂 ~ 2 ~ (2) ~ (17.732)) P 0.05 ~ (5) Stathmin. The positive expression rates of cin in cervical tissue and cervical carcinoma were 17.52.5% and 86.7%, respectively. The difference among the three groups was statistically significant (蠂 ~ (2 +) 67.1 ~ (-1) P0.05N. P27 and Stathmin protein expression was not related to the age of the patients. The expression of P0.05, P27 and Stathmin protein and the histological differentiation of cervical cancer were not related to the age of the patients. There was a significant correlation between lymph node metastasis and clinical stage. There was a negative correlation between the expression of Stathmin protein and the expression of P27 protein. Conclusion the detection of P27 protein and Stathmin protein can be used as a group of tumor markers in the diagnosis of cervical cancer. Protein can inhibit the expression of P27 protein, To promote the occurrence and development of cervical cancer.
【作者单位】：宁波市第二医院妇科;宁波市鄞州人民医院病理科;宁波市鄞州人民医院妇产科;
【分类号】：R737.33

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