大剂量戊酸雌二醇预防重度宫腔粘连分离术后再粘连的效果观察

发布时间：2018-02-20 17:14

本文关键词： 粘连宫腔粘连戊酸雌二醇分离术　出处：《山东医药》2015年21期 　论文类型：期刊论文

【摘要】：目的观察大剂量戊酸雌二醇在重度宫腔粘连分离术后预防再粘连的效果。方法选择行宫腔粘连分离术的重度宫腔粘连患者236例,随机分为观察组和对照组各118例,术后观察组口服戊酸雌二醇10 mg/d、对照组口服戊酸雌二醇5 mg/d,两组均于服用戊酸雌二醇第12天追加地屈孕酮10 mg/d口服,继续服药10 d,停药9 d后继续下个疗程,连续治疗3个疗程。术前及术后3个月检测两组凝血功能、血脂及肝功能指标,于术后6个月评价治疗效果及再粘连情况。结果术后6个月,观察组总有效率(95.76%)高于对照组(82.20%),观察组、对照组未见粘连带分别为71例(60.17%)、45例(38.14%),两组比较差异有统计学意义(P均0.01)。两组术前及术后3个月凝血功能、血脂及肝功能指标均在正常范围内,比较差异均无统计学意义(P均0.05)。在服药期间两组均未出现血栓性疾病、皮肤瘀斑、出血点等。结论重度宫腔粘连分离术后应用大剂量戊酸雌二醇可降低再粘连的发生率。
[Abstract]:Objective to observe the effect of high dose estradiol valerate on preventing readhesions after seperation of severe intrauterine adhesions. Methods 236 patients with severe intrauterine adhesions were randomly divided into observation group (n = 118) and control group (n = 118). After operation, estradiol valerate 10 mg / d in the observation group and estradiol valerate 5 mg / d in the control group were taken orally. Both groups were given diproprogesterone for 10 mg/d on the 12th day after taking estradiol valerate. After 9 days, the next course of treatment was continued. After 3 consecutive courses of treatment, coagulation function, blood lipid and liver function were measured before and 3 months after operation, and the therapeutic effects and adhesions were evaluated 6 months after operation. The total effective rate of observation group was higher than that of control group (82.20%). In the observation group, there were 71 cases (60.17) and 45 cases (38.14%) without adhesion zone in the control group. The difference between the two groups was statistically significant (P < 0.01). The coagulation function of the two groups before and 3 months after operation was significantly higher than that in the control group (P < 0.05). The indexes of blood lipid and liver function were within the normal range, and there was no significant difference between the two groups (P < 0.05). There were no thrombotic diseases and skin ecchymosis in the two groups during the treatment period. Conclusion large dose of estradiol valerate can reduce the incidence of re-adhesion after seperation of severe intrauterine adhesions.
【作者单位】：曹县人民医院;
【分类号】：R713.4

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