抗苗勒管激素在高龄妇女卵巢功能评估中的价值探讨

发布时间：2018-02-21 01:41

本文关键词： 抗苗勒管激素高龄妇女卵巢功能女性激素　出处：《中国妇幼保健》2016年19期 　论文类型：期刊论文

【摘要】：目的探讨抗苗勒管激素(Anti-mullerian hormone,AMH)在高龄妇女卵巢功能评估中的价值。方法收集2014年10月-2015年2月在柳州市妇幼保健院门诊接受咨询的高龄妇女100例,根据其月经状态将其分正常组32例,围绝经期组35例,卵巢早衰(Premature Ovarian Failure,POF)组33例,比较各组的黄体生成素(Luteinizing Hormone,LH)、卵泡刺激素(Follicle-Stimulating Hormone,FSH)、雌二醇(Estradiol,E2)和AMH水平,分析围绝经期组女性入组时、6个月、12个月时LH、FSH、E2和AMH水平变化,对比随访自然妊娠女性与非妊娠女性在入组时的LH、FSH、E2和AMH水平差异。结果围绝经期组血清FSH水平明显高于正常组(P0.05),AMH水平明显低于正常组(P0.05);POF组LH、FSH水平明显高于正常组和围绝经期组(P0.05),E2、AMH水平明显低于正常组和围绝经期组(P0.05)。围绝经期组入组后6个月、12个月时AMH水平较初测时均明显降低(P0.05),12个月时AMH水平较6个月时明显降低(P0.05);12个月时LH、FSH水平较初测、6个月时均明显升高(P0.05),E2水平较初测、6个月时均明显降低(P0.05)。正常组中妊娠妇女入组的初测AMH水平明显高于非妊娠妇女的初测水平(P0.05)。结论 AMH能较早、准确地反映高龄女性的卵巢功能变化,评估其自然受孕能力,因此在高龄妇女的生育能力评估中具有高的临床应用价值。
[Abstract]:Objective to investigate the value of anti-mullerian hormone AMH in the evaluation of ovarian function in elderly women. Methods 100 elderly women who received consultation in the outpatient clinic of Liuzhou Maternal and Child Health Hospital from October 2014 to February 2015 were collected. According to the menstrual state, 32 cases were divided into normal group, 35 cases in peri-menopausal period and 33 cases in premature Ovarian failure (POF) group. The levels of luteinizing Hormoneinizing LHH, Follicle-Stimulating HormoneFSHSH2, Estradiol E2 and Estradiolol E2 were compared. To analyze the changes of FSHE2 and AMH levels in peri-menopausal women at 6 months and 12 months, respectively. Results the serum FSH level in the perimenopausal group was significantly higher than that in the normal group (P 0.05) and that in the control group was significantly higher than that in the normal group. The level of P0.05E2AH in the peri-menopausal group was significantly lower than that in the normal group and the peri-menopausal group. The AMH level in the peri-menopausal group was significantly lower than that in the first measured group at 12 months, the AMH level at 12 months was significantly lower than that at 6 months, and at 12 months after menopause, it was significantly lower than that at 6 months after entering the group, and at 12 months after menopause, the AMH level was significantly lower than that at 6 months. The level of AMH in normal pregnant women was significantly higher than that in non-pregnant women (P 0.05). Conclusion the level of AMH was earlier in normal pregnant women than that in non-pregnant women, and the level of P0. 05% E 2 was significantly higher than that in normal women at 6 months, and the level of P0. 05% E 2 was significantly lower in normal pregnant women than that in non pregnant women at 6 months, and the level of P0. 05 in normal women was significantly higher than that in non pregnant women. It can accurately reflect the changes of the ovarian function of the elderly women and evaluate their natural ability to conceive, so it has high clinical application value in the evaluation of the fertility of the elderly women.
【作者单位】：柳州市妇幼保健院检验科;
【基金】：广西壮族自治区卫计委医学科研基金(Z2014374)
【分类号】：R711

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