宫颈癌组织中IDO表达与高危型人乳头瘤病毒感染的相关性研究

发布时间：2018-02-21 20:46

本文关键词： 宫颈癌吲哚胺 -二氧酶高危型人乳头瘤病毒　出处：《中国病原生物学杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的探讨宫颈癌组织中IDO表达与高危型人乳头瘤病毒(HPV)感染的相关性,为临床治疗提供指导。方法收集204例宫颈癌组织标本,PCR法检测宫颈癌患者高危型HPV感染情况,采用免疫组化法检测IDO蛋白表达情况,并分析宫颈癌组织IDO的表达与高危型HPV感染的相关性。结果 PCR检测宫颈癌患者感染高危型HPV16、HPV18目的片段大小分别为152和471bp;181例鳞癌患者中176例为高危型HPV感染,166例IDO阳性,相应的感染率和阳性率为97.24%和89.73%;21例腺癌患者中19例为高危型HPV感染,17例IDO阳性,相应的感染率和阳性率为90.48%和80.95%;2例腺鳞癌患者均为高危型HPV感染且IDO均阳性。204例宫颈癌患者高危型HPV感染率为96.57%(197/204),IDO阳性率为90.69%(185/204)。其中183例高危型HPV感染宫颈癌患者IDO阳性,占89.71%;7例高危型HPV阴性宫颈癌患者中IDO阳性2例,占0.98%。通过统计学分析宫颈癌患者IDO表达与高危型HPV感染具有相关性(OR值1)。结论宫颈癌患者高危型HPV的感染率与IDO表达率均较高,且两者具有相关性。
[Abstract]:Objective to investigate the correlation between IDO expression in cervical carcinoma and high-risk HPV infection, and to provide guidance for clinical treatment. Immunohistochemical method was used to detect the expression of IDO protein. The relationship between IDO expression in cervical carcinoma and high risk HPV infection was analyzed. Results the target fragment size of HPV16 HPV18 in cervical cancer patients was 152 and 471 bpP ~ (-1), respectively. 176 cases of high risk HPV infection were IDO positive. The corresponding infection rate and positive rate were 97.24% and 89.73 in 21 cases of adenocarcinoma, 19 cases were high risk type HPV infection and 17 cases were IDO positive. The corresponding infection rate and positive rate were 90.48% and 80.95 respectively. Two cases of adenosquamous carcinoma were all high risk HPV infection and two cases of IDO were positive. The positive rate of high risk type HPV was 96.577.97 / 204 of cervical cancer patients. The positive rate of HPV was 90.69% 1855% / 204%, among which, 183 cases of high risk HPV infected cervical cancer patients were IDO positive. There were 2 cases (0.98%) of IDO positive in 7 cases of high-risk HPV negative cervical cancer. There was a correlation between IDO expression and high risk HPV infection in cervical cancer patients by statistical analysis. Conclusion the infection rate and IDO expression rate of high risk type HPV in cervical cancer patients are higher than those in cervical cancer patients. And there is a correlation between the two.
【作者单位】：天津医科大学病理学教研室;天津市滨海新区大港医院神经外科;
【分类号】：R737.33

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