CMV-IgG亲和力鉴别孕妇原发性CMV感染的意义

发布时间：2018-02-22 04:38

  本文关键词： CMV 抗体亲和力 产前诊断 临床意义　出处：《广东医学》2017年07期 　论文类型：期刊论文

【摘要】：目的检测孕妇样本CMV-IgG抗体亲和力,对排除和确认原发性巨细胞病毒(CMV)感染的性能进行分析,为孕妇CMV感染诊断提供参考依据。方法收集符合要求的114例血清样本,根据血清学状态分为原发感染组(第1组)、既往感染组(第2组)以及无血清转换记录的CMV感染待定组(第3组),测定样本CMVIgG抗体亲和力,根据第1组和第2组结果分析该方法排除或确认原发性CMV感染的性能,并通过测定无血清转换记录的样本CMV-IgG亲和力来说明该方法在临床检测中的意义。结果第1组CMV-IgG抗体亲和力结果显示27例(93.1%,27/29)孕妇的AI处于20%~45%,1例孕妇CMV-IgG抗体AI50%。第2组41例(91.1%)孕妇AI50%,35例(77.8%)孕妇AI60%,显示高亲和力。第3组12例(30.0%)孕妇AI45%,2例(5.0%)孕妇CMV-IgG抗体亲和力中等(45.0%~55.0%),26例(65.0%)孕妇AI60%。结论 CMV-IgG亲和力测定确认和排除CMV近期感染的性能良好、提高了血清学诊断,能够有效防止侵入性产前诊断。
[Abstract]:Objective to detect the affinity of CMV-IgG antibody in pregnant women, to analyze the ability to exclude and confirm the primary cytomegalovirus (CMV) infection, and to provide a reference basis for the diagnosis of CMV infection in pregnant women. According to the serological status, the patients were divided into primary infection group (group 1), previous infection group (group 2) and unrecorded CMV infection group (group 3). According to the results of the first and second groups, the performance of this method to exclude or confirm primary CMV infection was analyzed. The significance of this method in clinical test was demonstrated by measuring the CMV-IgG affinity of samples without serum-conversion record. Results the results of CMV-IgG antibody affinity in group 1 showed that 27 pregnant women with CMV-IgG antibody were at 2045454545g. Group 2. 41 cases (91.1%) pregnant women AI50 / 35 cases (77.8%) pregnant women showed high affinity. Group 3 (12 cases: 30.0%) pregnant women had 2 cases (5.0%) pregnant women had moderate CMV-IgG antibody affinity (45.0% 55.0%), 26 cases (65.0). Conclusion CMV-IgG affinity test can confirm and exclude recent infection of CMV. Improved serological diagnosis can effectively prevent invasive prenatal diagnosis.
【作者单位】： 广东省中医院检验科;广东省妇幼保健院医学遗传中心;广州市妇女儿童医疗中心优生围产研究所;
【分类号】：R714.251;R446.1
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