妊娠期肝内胆汁淤积症161例临床分析

发布时间：2018-02-22 04:54

本文关键词： 妊娠期肝内胆汁淤积症母婴结局　出处：《中国妇产科临床杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的探讨妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)对母婴结局的影响。方法收集2011年5月至2016年12月在上海交通大学医学院附属苏州九龙医院接受治疗的161例ICP患者为研究组,根据患者的血清总胆汁酸水平将其分为轻度组(116例)与重度组(45例),观察两组患者母婴结局的差异。结果重度组总胆汁酸(total bile acid,TBA)谷丙转氨酶(alanine aminotransferase,ALT)以及谷草转氨酶(aspartate aminotransferase,AST)水平显著高于轻度组,差异有统计学意义(P0.05),重度组终止妊娠时间和阴道分娩比例显著低于轻度组,差异有统计学意义(P0.05),轻度组与重度组的产后出血比列、新生儿体重及Apgar评分无明显差别,差异均无统计学意义(P0.05)。结论妊娠期ICP是导致不良母婴结局的一项重要原因,应加强对产妇的产前检查以及围生期的胎儿监护护理。
[Abstract]:Objective to investigate the effect of intrahepatic cholestasis of pregnancy (cholestasis) on maternal and infant outcomes. Methods from May 2011 to December 2016, 161 patients with ICP received treatment in Suzhou Jiulong Hospital, School of Medicine of Shanghai Jiaotong University as study group. According to the serum total bile acid level, the patients were divided into mild group (116 cases) and severe group (45 cases). The difference of maternal and infant outcomes between the two groups was observed. Results Total total bile acid of patients in severe group (total bile acid total bile acidad TBA) alanine aminotransferase (alt) and alanine aminotransferase (alt) were observed. The level of aspartate aminotransferase (AST) was significantly higher in mild group than that in mild group. The time of termination of pregnancy and the proportion of vaginal delivery in severe group were significantly lower than those in mild group (P 0.05). There was no significant difference in postpartum hemorrhage ratio between mild group and severe group. There was no significant difference in neonatal weight and Apgar score between mild group and severe group. Conclusion ICP during pregnancy is an important cause of adverse maternal and infant outcomes. Prenatal examination and perinatal care should be strengthened.
【作者单位】：上海交通大学医学院附属苏州九龙医院妇产科;
【分类号】：R714.255

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