不孕妇女支原体感染调查与药物敏感性研究

发布时间：2018-02-23 12:15

本文关键词： 支原体不孕不育妇女药敏试验　出处：《中华医院感染学杂志》2017年11期 　论文类型：期刊论文

【摘要】：目的探讨不孕妇女支原体感染状况与药物敏感性研究,为临床诊治提供参考依据。方法回顾性分析2010年8月-2016年8月医院不孕不育专科收治的不孕不育妇女925例,提取患者宫颈分泌物进行药敏试验,统计患者的支原体感染率及药敏率和耐药率。结果 925例不孕妇女中有786例发生支原体感染,感染率84.97%,其中629例发生解脲脲支原体(Uu)感染占80.02%,45例发生人支原体(Mh)感染占5.73%,112例发生Uu+Mh混合感染占14.25%;786例支原体感染患者年龄多分布在25~30岁占总数的67.56%,各不同类型支原体感染均多分布在25~30岁,而合并感染中分布36~40岁患者比例明显增多(P0.05);Uu对交沙霉素最敏感(92.05%),耐药率最高的是环丙沙星(67.72%),Mh对壮观霉素最敏感(86.67%),耐药率最高的是克拉霉素(93.33%),支原体阳性菌株对抗菌药物的多药耐药显示,Uu多为4~6种抗菌药物耐药比例为63.12%,Mh多药耐药多在10种以上达42.22%,合并感染多药耐药多在10种抗菌药物以上比例达51.79%。结论不孕不育妇女支原体感染率较高,尤其是Uu感染,年龄在25~30岁的妇女易感染疾病,对不孕妇女应加强支原体检测和药敏试验,其中交沙霉素、克拉霉素、壮观霉素和强力霉素可作为支原体感染的首选药物。
[Abstract]:Objective to study the infection status and drug sensitivity of mycoplasma in infertile women, and to provide reference for clinical diagnosis and treatment. Methods 925 infertile women admitted in hospital from August 2010 to August 2016 were retrospectively analyzed. The mycoplasma infection rate, drug sensitivity rate and drug resistance rate were calculated. Results 786 of 925 infertile women developed mycoplasma infection. The infection rate was 84.97, of which 629 cases had Ureaplasma Urealyticum Ureaplasma Ureaplasma Urealyticum (UUU) infection (80.02%) and 45 cases (45 cases) of Ureaplasma Urealyticum (UU) infection accounted for 5.73% (112 cases) and 112 cases of UU Mh mixed infection (14.25%). 786 cases of mycoplasma infection were mostly distributed in the age of 2530 years and accounted for 67.56% of the total. Most of mycoplasma infection occurred in 2530 years old. However, the proportion of patients aged 36 to 40 years with co-infection increased significantly. P0.05Uu was most sensitive to josamycin and 92.05%. The most sensitive drug resistance rate was ciprofloxacin 67.72 Mh to spectinomycin, and the highest drug resistance rate was clarithromycin 93.3333B. mycoplasma positive strains were antagonistic to spectinomycin, and the most sensitive to spectinomycin was ciprofloxacin 67.72Mh, and the highest drug resistance rate was clarithromycin 93.33B. The multidrug resistance of bacterial drugs showed that the ratio of 6 kinds of antimicrobial drug resistance to UU was 43.12Mh was more than 10, and that of co-infection was 51.79. Conclusion the infection rate of mycoplasma in infertile women is higher than that in infertile women. Especially for UU infection, women aged 25 ~ 30 years are susceptible to infection. Mycoplasma detection and drug sensitivity test should be strengthened in infertile women. Among them, josamycin, clarithromycin, spectinomycin and doxycycline can be used as the first choice for mycoplasma infection.
【作者单位】：绵阳市中心医院妇产科;
【分类号】：R711.6

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