胚胎停育患者血清及组织中IL-6表达

发布时间：2018-03-02 00:08

本文关键词： 胚胎停育血清绒毛组织蜕膜组织白细胞介素-　出处：《现代仪器与医疗》2016年06期 　论文类型：期刊论文

【摘要】：目的 :检测胚胎停育患者血清及组织中白细胞介素-6(IL-6)表达水平,探讨IL-6对胚胎停育的影响。方法 :将我院2014年5月~2016年5月收治的74例胚胎停育患者纳入胚胎停育组,并选取同期50名正常早孕女性、50名健康未孕女性,分别纳入早孕组、健康组,检测各组受试者血清IL-6水平及绒毛、蜕膜组织IL-6表达水平。结果 :胚胎停育组与早孕组年龄、停经时间、孕次、孕囊直径比较,差异无统计学意义(P0.05)。胚胎停育组血清IL-6水平低于早孕组、健康组,早孕组血清IL-6水平高于健康组,差异有统计学意义(P0.05);胚胎停育组绒毛组织、蜕膜组织IL-6表达水平均低于早孕组,差异有统计学意义(P0.05)。结论:胚胎停育患者血清及组织中IL-6表达水平显著下降,这可能是造成其早期胚胎停止发育原因之一。
[Abstract]:Objective: to detect the expression of interleukin-6 (IL-6) in serum and tissue of patients with fetal arrest, and to explore the effect of IL-6 on fetal suspension. Methods: 74 patients with fetal arrest were admitted to our hospital from May 2014 to May 2016. The serum IL-6 levels, villi and decidua IL-6 expression levels were measured in 50 normal early pregnant women and 50 healthy non-pregnant women in the same period. Results: the age of fetal suspension group and early pregnancy group were determined. There was no significant difference in menopausal time, pregnancy time and gestational sac diameter. The serum IL-6 level in fetal suspension group was lower than that in early pregnancy group, and the serum IL-6 level in healthy group and early pregnancy group was higher than that in healthy group (P 0.05). The expression of IL-6 in decidual tissues was significantly lower than that in early pregnancy group (P 0.05). Conclusion: the expression of IL-6 in serum and tissues of patients with fetal arrest is significantly decreased, which may be one of the reasons for the cessation of early embryo development.
【作者单位】：南京大学医学院附属金陵医院南京军区南京总医院临床中心实验科;江苏省钟山干部疗养院检验科;南京大学医学院附属金陵医院南京军区南京总医院妇产科;
【分类号】：R714.2

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