保妇康栓联合抗HPV生物蛋白敷料治疗高危型HPV感染的临床疗效

发布时间：2018-03-04 18:25

本文选题：保妇康栓　切入点：抗HPV生物蛋白敷料　出处：《湖北中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的探讨保妇康栓联合抗HPV生物蛋白敷料治疗宫颈高危型人乳头瘤病毒感染(主要为HPV16或18型感染)的有效性,试图寻找一种有效的抗高危型HPV感染的方法,从而及时阻止疾病的进一步发展,降低癌前病变及宫颈癌的发生率。方法选取武汉市第四医院2016年1月至2016年9月门诊收治的90例确诊为宫颈高危型HPV感染的患者,随机分成3组,每组30例,均在月经干净3天后开始用药,于每晚睡前用温水清洗外阴后将药物置于阴道后穹隆,用药和观察期间若有性生活需使用避孕套。保妇康栓组:1次/d,2粒/次,16天1个疗程,连用3个疗程;抗HPV生物蛋白辅料组:1支/d,隔日1次,10次1个疗程,连用3个疗程;联合用药组:抗HPV生物蛋白敷料1支/d,保妇康栓2粒/d,两药交替使用,各用10天,20天为一疗程,连用3个疗程。在停药一个月后分别复查每组患者的临床症状(分泌物多、性交后出血)、宫颈糜烂程度、实验室检查(HPV分型、血常规、尿常规、肝功能、肾功能);停药三个月后再次对每组患者进行HPV分型检测。结果1、停药一个月后保妇康栓联合抗HPV生物蛋白敷料治疗高危型HPV感染疗效显著,总有效率达76.7%,明显高于其他两组(保妇康栓组总有效率46.7%,抗HPV生物蛋白敷料组总有效率66.7%)。2、停药一个月后保妇康栓联合抗HPV生物蛋白敷料治疗高危型HPV感染的临床症状改善显著,总有效率达70%,明显高于其他两组(保妇康栓组总有效率33%,抗HPV生物蛋白敷料组总有效率53%)。3、停药一个月后保妇康栓联合抗HPV生物蛋白敷料、保妇康栓组、抗HPV生物蛋白敷料组治疗宫颈糜烂的有效率分别为16.7%、10%、6.67%,差异无统计学意义(P0.05)。4、安全性观察:三组患者治疗前后血常规、尿常规、肝功能、肾功能均无异常变化,未出现不良事件。5、停药三个月后保妇康栓联合抗HPV生物蛋白敷料治疗高危型HPV感染疗效显著,总有效率达86.7%,明显高于其他两组(保妇康栓组总有效率66.7%,抗HPV生物蛋白敷料组总有效率73.3%)。结论保妇康栓联合抗HPV生物蛋白敷料治疗高危型HPV感染疗效显著,能明显改善临床症状,提高hr-HPV转阴率,疗效优于单用其中任何一种药物,且临床应用安全可靠,无明显毒副作用。
[Abstract]:Objective to explore the efficacy of Baofukang suppository combined with anti-#en0# bioprotein dressing in the treatment of high-risk human papillomavirus infection (mainly HPV16 or type 18 infection), and to find an effective method for the treatment of high-risk HPV infection. In order to prevent the further development of the disease and reduce the incidence of precancerous lesions and cervical cancer in time, 90 patients diagnosed as high-risk cervical HPV infection were selected from January 2016 to September 2016 in Wuhan 4th Hospital. They were randomly divided into 3 groups, 30 cases in each group, all of whom began taking drugs after 3 days of menstruation, and then washed the vulva with warm water before going to bed every night, then placed the drugs in the posterior vagina fornix. During the period of medication and observation, condoms should be used if there was sexual life. In the Baofukang suppository group, one treatment course was 1: 1 / d / L, and 3 courses of treatment were continuously used, while in the anti HPV bioprotein excipient group, 10 courses of treatment were given 10 times a day, and 3 courses of treatment were continued, and that of the anti HPV bioprotein excipients group was 10 times a day, 10 times a course of treatment every other day. The combined treatment group: 1 / d of anti HPV biological protein dressing, 2 / d of Baofukang suppository, 2 / d of Baofukang suppository, alternately used for 10 days and 20 days each as a course of treatment, 3 consecutive courses of treatment. After one month of withdrawal, the clinical symptoms (more secretions) of each group were re-examined respectively. Bleeding after sexual intercourse, degree of cervical erosion, laboratory examination of HPV typing, blood routine, urine routine, liver function, After three months of withdrawal, HPV typing was performed again in each group. Results 1. One month after withdrawal, Baofukang suppository combined with anti HPV bioprotein dressing was effective in the treatment of high risk HPV infection. The total effective rate was 76. 7, which was significantly higher than that of the other two groups (the total effective rate of Baofukang suppository group was 46. 7%, the total effective rate of anti-HPV bioprotein dressing group was 66. 7%. The clinical symptoms of Baofukang suppository combined with anti-HPV bioprotein dressing in the treatment of high-risk HPV infection were improved significantly after one month. The total effective rate was significantly higher than that of the other two groups (Baofukang suppository group, anti-#en0# bioprotein dressing group, total effective rate, 530.3. one month after the withdrawal, Baofukang suppository combined with anti-#en1# bioprotein dressing, Baofukang suppository combined with anti-#en1# bioprotein dressing, Baofukang suppository group, Baofukang suppository group, The effective rates of anti-#en0# bioprotein dressing group were 16.710 and 6.67, respectively. The difference was not statistically significant (P0.05. 4). Safety observation: before and after treatment, there were no abnormal changes in blood routine, urine routine, liver function and renal function in the three groups of patients, and there were no abnormal changes in blood routine examination, urine routine examination, liver function and renal function before and after treatment. There were no adverse events. 5. The efficacy of Baofukang suppository combined with anti HPV bioprotein dressing in the treatment of high risk HPV infection was significant three months after withdrawal. The total effective rate was 86.7, which was significantly higher than that of the other two groups (the total effective rate of Baofukang suppository group was 66.7, and the total effective rate of anti-#en0# bioprotein dressing group was 73.30.Conclusion the efficacy of Baofukang suppository combined with anti-#en1# bioprotein dressing in the treatment of high-risk HPV infection was significant. It can obviously improve the clinical symptoms and increase the negative rate of hr-HPV. The curative effect is better than that of any one of the drugs alone, and the clinical application is safe and reliable, and there is no obvious side effect.
【学位授予单位】：湖北中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.33

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