重度子痫前期病人血清补体C3a、C5a水平及其与肾功能损害的关系

发布时间：2018-03-04 19:09

本文选题：先兆子痫　切入点：补体Ca　出处：《青岛大学医学院学报》2016年06期 　论文类型：期刊论文

【摘要】：目的探讨重度子痫前期病人血清补体C3a、C5a水平与肾功能损害的关系。方法重度子痫前期病人68例(子痫前期组),采用酶联免疫吸附试验(ELISA)方法检测血清补体C3a、C5a水平,并检测血清尿素氮(BUN)、肌酐(Cr)、尿酸(UA)、胱抑素-C(Cys-C)及24h尿蛋白总量,计算肌酐清除率(CCr)。以同期正常单胎足月妊娠孕妇60例为对照组。结果子痫前期组血清C3a、C5a、BUN、Cr、UA、Cys-C水平及24h尿蛋白总量明显高于对照组,差异有显著性(t=2.02~31.35,P0.05);子痫前期组CCr较对照组明显减低,差异有显著性(t=16.02,P0.05)。子痫前期组血清C3a、C5a水平与BUN、Cr无明显相关性(P0.05);与UA、Cys-C及24h尿蛋白总量呈明显正相关(r=0.245~0.491,P0.05),与CCr呈明显负相关(r=-0.267、-0.281,P0.05)。结论重度子痫前期病人血清补体C3a、C5a水平升高,并且与肾功能损害有关。
[Abstract]:Objective to investigate the relationship between serum complement C3a1 C5a level and renal function damage in patients with severe preeclampsia. Methods 68 patients with severe preeclampsia (pre-eclampsia group) were examined for serum complement C3aFC5a level by Elisa. The contents of serum urea nitrogen bun, creatinine, uranine, cystatin, cystatin, cystatin, and 24 hours urine protein were determined. The creatinine clearance rate and creatinine clearance rate were calculated. 60 pregnant women with normal single term pregnancy were taken as control group. Results the levels of serum C3aC5aBUNC and 24 hours urine protein in preeclampsia group were significantly higher than those in control group, and the difference was significant. The CCr in preeclampsia group was significantly lower than that in control group, while in preeclampsia group it was significantly lower than that in control group, and the level of serum Cys-C in preeclampsia group was significantly higher than that in control group. There was a significant difference between serum C3a C5a level and bun Cr in preeclampsia group (P 0.05a), a positive correlation between Cys-C and 24 h urine protein content in UAU, and a negative correlation between C3a C5a level and CCr in severe preeclampsia patients. Conclusion the level of complement C5a in serum of patients with severe preeclampsia is higher than that of P0.05a in patients with severe preeclampsia, and it is negatively correlated with the serum levels of C3a and C5a in patients with severe preeclampsia, and is negatively correlated with CCr in patients with severe preeclampsia (P < 0.05), but not in patients with severe preeclampsia (P < 0.05). And associated with renal impairment.
【作者单位】：青岛大学附属医院产科;青岛大学附属医院妇科;
【分类号】：R714.244

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