温经祛瘀方对子宫内膜病变不孕症患者体外受精-胚胎移植周期子宫内膜容受性的影响

发布时间：2018-03-05 22:21

本文选题：体外受精-胚胎移植　切入点：子宫内膜容受性　出处：《广东医学》2015年08期 　论文类型：期刊论文

【摘要】：目的探讨温经祛瘀方对子宫内膜病变不孕症患者体外受精-胚胎移植(IVF-ET)周期子宫内膜容受性与临床妊娠的影响。方法将72例接受IVF-ET的子宫内膜病变不孕症患者随机分为观察组(41例)和对照组(31例),对照组单纯宫腔镜下诊刮送病理检查后采用常规控制性超促排卵方案,观察组在对照组治疗的基础上辨证运用温经祛瘀方进行中药干预,观察两组患者IVF-ET周期临床与实验室相关检测指标变化。结果温经祛瘀方可以显著提高观察组子宫内膜病变不孕患者HCG注射日A型子宫内膜形态,降低C型或不均质子宫内膜的发生率(P0.01),生化妊娠率高于对照组(P0.05),胚胎种植率与临床妊娠率均高于对照组但差异无统计学意义(P0.05)。两组患者HCG注射日子宫内膜厚度、B型内膜、周期取消率比较差异均无统计学意义(P0.05)。使用中药干预的不孕患者种植窗期胞饮突表达丰富明显。结论温经祛瘀方对IVF-ET周期子宫内膜病变不孕症患者可有效改善子宫内膜容受性,提高胚胎种植率与临床妊娠率。
[Abstract]:Objective to investigate the effect of Wenjing Quyu recipe on endometrial receptivity and clinical pregnancy in patients with infertility due to endometrial lesions in vitro fertilization and embryo transfer (IVF-ETT) cycle. Methods 72 cases of infertility with endometrial lesions received IVF-ET were followed up. The patients were divided into observation group (n = 41) and control group (n = 31). Observation group on the basis of treatment in the control group on the basis of syndrome differentiation, warming meridian dispelling blood stasis prescription for Chinese medicine intervention, The clinical and laboratory indexes of IVF-ET cycle were observed in two groups. Results Wenjing Quyu recipe could significantly improve the pattern of type A endometrium on the day of HCG injection in patients with endometriosis in the observation group. The incidence of type C or uneven endometrium was decreased (P 0.01), the rate of biochemical pregnancy was higher than that of control group (P 0.05), the rate of embryo implantation and clinical pregnancy was higher than that of the control group, but there was no significant difference between the two groups (P 0.05). The thickness of endometrium in the two groups on the day of HCG injection was more than that of type B endometrium. There was no significant difference in the rate of cycle cancellations (P 0.05). There was a significant increase in the expression of cell processes in the implantation window of infertility patients treated with traditional Chinese medicine. Conclusion Wenjing Quyu recipe can effectively improve the endometrial receptivity of infertility patients with endometrial lesions in IVF-ET cycle. Increase embryo implantation rate and clinical pregnancy rate.
【作者单位】：江苏省连云港市妇幼保健院生殖医学中心;
【基金】：江苏省中医药管理局科技计划项目(编号:LB11031)
【分类号】：R714.8

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