遵义地区孕妇乙型肝炎病毒感染及乙肝五项定量调查研究

发布时间：2018-03-08 05:21

本文选题：乙型肝炎病毒　切入点：感染　出处：《中华医院感染学杂志》2017年03期 　论文类型：期刊论文

【摘要】：目的调查研究遵义地区孕妇乙型肝炎病毒(HBV)感染及乙肝五项定量,为HBV在母婴传播中的预防提供参考。方法选取2014年1月-2016年6月医院住院孕妇2 648例,以金标法检测HBsAg,HBsAg阳性者采用时间分辨荧光免疫分析技术检测乙肝五项定量,荧光定量PCR法检测HBV-DNA,分析结果。结果 2 648例孕妇中有HBsAg阳性者243例,HBV感染率为9.18%;HBV感染孕妇HBV-DNA检测阳性者134例,阴性109例,阳性构成比为55.14%;HBV感染者以HBsAg+HbeAb+HBcAb阳性者所占比例最高,其次为HBsAg+HBcAb、HBsAg+HBeAg+HBcAb阳性,构成比分别为30.45%、25.93%、17.28%,单纯HBsAg阳性者12例,占4.94%;HBsAg+HBeAg+HBcAb模式42例孕妇HBV-DNA均为阳性,阳性率100.00%,HBsAg+HBeAg、HBsAg+HBeAg+HBeAb+HBcAb、HBsAg+HBeAb、HBsAg+HBcAb、HBsAg+HBeAb+HBcAb、HBsAg+HBsAb模式下HBV-DNA阳性率分别为81.82%、72.73%、71.43%、49.21%、37.84%、8.33%;HBVDNA阳性HBV感染孕妇HBsAg、HBeAg高于HBV-DNA阴性孕妇,HBsAb、HbeAb、HBcAb低于HBV-DNA阴性孕妇,比较差异有统计学意义(P0.05)。结论遵义地区孕妇中存在一定比例HBV感染,乙肝五项定量能较好反应出HBV复制活跃程度,与HBV-DNA关系密切。
[Abstract]:Objective to investigate the hepatitis B virus (HBV) infection and hepatitis B virus (HBV) infection in pregnant women in Zunyi area, and to provide a reference for the prevention of HBV in mother-to-child transmission. Methods from January 2014 to June 2016, 2 648 pregnant women in hospital were selected. Using gold standard method to detect HBsAg positive patients, 5 items of hepatitis B were detected by time-resolved fluorescence immunoassay (TLIA). Results the positive rate of HBV-DNA in 243 out of 2648 pregnant women was 9.18. 134 cases were positive for HBV-DNA and 109 cases were negative for HBV-DNA. The positive ratio was 55.14% of HBV-infected persons, followed by HBsAg HBcAb-HBsAg HBeAg HBcAb positive, HBsAg HBcAb-HBsAg HBeAg HBcAb was 30.4545 + 25.93% and 17.28%, only 12 cases were HBsAg positive, accounting for 4.94HBAg-#en7# HBcAb model 42 pregnant women were all positive HBV-DNA. The positive rate of HBeAg was 100.00HBeAg HBeAg HBeAg HBeAb HBcAbmHBeHBeAbHBeHBeAbHBeHBeHAb HBeAb HBcAbn HBsAg HBeAb HBcAbn HBsAg HBsAb positive rate was 81.822.72.730.71.430.The positive rate of HBeAg in HBV-DNA positive HBV infected pregnant women with HBV-DNA was higher than that in HBV-DNA negative pregnant women (HBcAb) was lower than that in HBV-DNA negative pregnant women (P < 0.05), and the positive rate of HBeAg in HBV-DNA positive HBV infected pregnant women was higher than that in HBV-DNA negative pregnant women (HBeAg) was lower than that in HBV-DNA negative pregnant women (P < 0.05). Conclusion there is a certain proportion of HBV infection in pregnant women in Zunyi area. The activity of HBV replication can be well reflected by the five quantification of hepatitis B, which is closely related to HBV-DNA.
【作者单位】：遵义市第一人民医院妇产科;遵义市红花岗区疾病预防控制中心;
【基金】：国家自然科学基金面上项目资助项目(81572438)
【分类号】：R714.251

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