血浆同型半胱氨酸水平与妊娠期高血压疾病的关系

发布时间：2018-03-10 06:33

本文选题：妊娠期高血压疾病　切入点：同型半胱氨酸　出处：《山东医药》2015年25期 　论文类型：期刊论文

【摘要】：目的探讨血浆同型半胱氨酸(Hcy)水平与妊娠期高血压疾病的关系。方法选择180例妊娠期高血压疾病患者作为实验组,其中妊娠期高血压、子痫前期轻度、子痫前期重度各60例;随机选取60例同期正常孕晚期孕妇作为对照1组,并选取同期因先兆流产硫酸镁保胎治疗患者60例作为对照2组。子痫前期轻度、重度及先兆流产患者入院当天用硫酸镁解痉、保胎治疗后第1、3、5、7、28天,采用荧光偏振免疫分析法检测血浆Hcy浓度。结果妊娠期高血压疾病患者血浆Hcy水平随着病情加重不断升高,与对照1组相比有统计学差异(P均0.01);经过硫酸镁治疗后子痫前期轻度、子痫前期重度患者血浆Hcy水平逐渐降低,与对照2组比较差异有统计学意义(P均0.01)。结论血浆Hcy在妊娠期高血压疾病患者中随着病情进展不断升高,密切监测其变化,对妊娠期高血压疾病的治疗、病情监测及预防有重要意义。
[Abstract]:Objective to investigate the relationship between plasma homocysteine (Hcy) level and hypertensive disorder complicating pregnancy. Methods 180 patients with hypertensive disorder complicating pregnancy were selected as experimental group, including 60 cases of gestational hypertension, 60 cases of mild preeclampsia and 60 cases of severe preeclampsia. 60 pregnant women with normal late pregnancy were randomly selected as control group, and 60 patients with preeclampsia treated with magnesium sulfate were selected as control group 2. The patients with mild, severe and preeclampsia were treated with magnesium sulfate on the day of admission. The plasma Hcy concentration was measured by fluorescence polarization immunoassay on day 28 after fetal preservation treatment. Results the plasma Hcy level in patients with hypertensive disorder complicating pregnancy increased with the severity of the disease. Compared with the control group, there was a significant difference between the two groups (P < 0.01). After magnesium sulfate treatment, the plasma Hcy level decreased gradually in the patients with mild preeclampsia and severe preeclampsia. Conclusion Plasma Hcy in patients with hypertensive disorder complicating pregnancy is increased with the development of the disease, the changes of plasma Hcy are closely monitored, and the treatment of hypertensive disorder complicating pregnancy is closely monitored. Monitoring and prevention of the disease is of great significance.
【作者单位】：上海市嘉定区南翔医院;上海中医药大学附属曙光医院;
【基金】：上海市嘉定区科学技术发展基金(2010124)
【分类号】：R714.246

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