反复种植失败患者中药左归丸干预的临床效果分析

发布时间：2018-03-10 08:02

本文选题：生殖技术　切入点：辅助　出处：《国际生殖健康/计划生育杂志》2016年06期 　论文类型：期刊论文

【摘要】：目的:探讨反复种植失败(RIF)患者冻融胚胎移植(FET)周期中药左归丸临床应用效果。方法:选择2014年6月—2015年12月于兰州大学第一医院生殖医学专科医院采用促性腺激素释放激素激动剂(GnRHa)降调节激素替代方案准备子宫内膜进行FET周期的RIF患者80例,根据随机数字表法,分为中药组(40例)和对照组(40例)。中药组予GnRHa降调节4个周期,每个周期间加用中药左归丸14 d。对照组只予GnRHa降调节4个周期。观察2组患者降调节期间临床症状,人绒毛膜促性腺激素(h CG)日和移植日血清性激素水平及临床妊娠率,血流指标。结果:2组患者hCG日雌二醇(E_2)、黄体生成激素(LH)及移植日孕激素(P)比较差异无统计学意义(均P0.05)。中药组移植日E_2、胚胎种植率及临床妊娠率均高于对照组(均P0.05)。与对照组比较,中药组子宫内膜基底动脉阻力指数(RI)降低,阴道超声显示子宫内膜-肌层交界(EMI)区回声有所改善,差异有统计学意义(均P0.05),两组间内膜基底区搏动指数(PI)及血流分支差异无统计学意义(均P0.05)。降调期予中药治疗后潮热出汗、腰膝酸软等肾阴虚症状明显改善(均P0.05)。结论:中药左归丸可协调激素水平,改善降调节期间肾阴虚症状,改善子宫内膜血流,从而增加胚胎种植率。
[Abstract]:Objective: to investigate the clinical application effect of Zuogui Pill, a traditional Chinese medicine for frozen and thawed embryo transfer (FET) cycle in patients with recurrent failed implantation RIFs. Methods: gonadotropin gonadotropin was used in the first Hospital of Reproductive Medicine of Lanzhou University from June 2014 to December 2015. The hormone releasing hormone agonist (GnR Ha) down-regulated hormone replacement regimen was used to prepare the endometrium for FET cycle in 80 patients with RIF. According to the random digital table method, it was divided into Chinese medicine group (n = 40) and control group (n = 40). The traditional Chinese medicine group was given GnRHa descending regulation for 4 cycles. Zuo Gui Pill was added every week for 14 days. The control group was given only 4 cycles of GnRHa down-regulation. The clinical symptoms, serum sex hormone level and clinical pregnancy rate were observed in the two groups during the down-regulation period, the day of HCG and the day of transplantation. Results there was no significant difference in serum estradiol, luteinizing hormone (LH) and progesterone (P < 0.05) between the two groups on the day of hCG. The embryo implantation rate and the clinical pregnancy rate in the traditional Chinese medicine group were higher than those in the control group (P < 0.05). Compared with the control group, In the traditional Chinese medicine group, the resistance index of endometrium basilar artery (RI) was decreased, and the echo of endometrium-myometrium junction (EMII) area was improved by vaginal ultrasound. The difference was statistically significant (P 0.05), and there was no significant difference between the two groups (P0. 05) and blood flow branches (P0. 05%, P 0. 05). After the treatment of traditional Chinese medicine, there was no significant difference between the two groups in the perspiration of hot flashes. Conclusion: Zuo Gui Pill can coordinate hormone level, improve kidney yin deficiency symptom, improve endometrial blood flow and increase embryo implantation rate.
【作者单位】：兰州大学第一医院生殖医学专科医院;甘肃中医药大学附属医院针灸中心;
【基金】：甘肃省省青年科技基金计划(1606RJYA273)
【分类号】：R714.8

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