血清卵泡抑素与卵巢子宫内膜异位症相关性分析

发布时间：2018-03-13 05:17

本文选题：子宫内膜异位症　切入点：卵泡抑素　出处：《兰州大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：探讨血清卵泡抑素(follistatin,FS)水平与子宫内膜异位症(Endometriosis,EMT,内异症)的相关性,及其在卵巢型内异症诊断方面的意义。方法：选取50例内异症患者空腹外周血标本为研究组,其中包含卵巢型内异症30例和卵巢外内异症20例(本研究中卵巢外内异症组主要包括子宫腺肌症10例、腹壁疤痕内异症6例和盆腔内异症4例),选取30例卵巢良性肿瘤患者空腹外周血标本和50例正常健康女性月经周期中期空腹外周血标本为对照组,分别用酶联吸附试验(enzyme-linked immuno sorbent assay,ELISA)和电化学发光实验(electrochemiluminescence immunoassay,ECLIA)测定50例内异症患者、30例卵巢良性肿瘤患者及50例正常健康妇女血清FS和癌抗原125(cancer antigen125,CA125)水平,并采用受试者工作特征(receiver operator characteristic,ROC)曲线比较FS和CA125对内异症诊断的敏感度和特异性。结果：卵巢型EMT组血清FS水平(1332.74±305.54ng/L)与卵巢良性肿瘤组(308.61±54.39ng/L)和正常组对照72.12±48.97ng/L)相比均有统计学意义(P0.05)。卵巢型EMT组血清CA125水平(52.02±22.64U/mL)较卵巢良性中瘤组(35.21±18.32U/mL)和正常组(18.72±6.17U/mL)均有显著差异(P0.001),但其与卵巢外EMT组血清CA125水平(46.53±27.66U/mL)相比无明显差异(P=0.295)。结论：内异症患者血清FS的表达水平显著升高,对于早期内异症(尤其对卵巢型内异症)的诊断有重要的临床参考价值,有希望成为内异症早期诊断的另一血清学指标。
[Abstract]:Objective: to investigate the relationship between serum follistatinn (FSs) level and Endometriosisus Endometriosisus (Endometriosisus Endometriosisus Endometriosisus (EMT)) and its significance in the diagnosis of ovarian endometriosis. Methods: fasting peripheral blood samples of 50 patients with endometriosis were selected as study group, including 30 patients with ovarian type endometriosis and 20 patients with extraovarian endometriosis. In this study, 10 cases of uterine adenomyosis were included in the group of extraovarian endometriosis. There were 6 cases of abdominal scar endogeneity and 4 cases of pelvic endometriosis. 30 patients with benign ovarian tumor and 50 healthy women with middle menstrual cycle were selected as control group. Serum FS and cancer antigen125CA125 were measured by enzyme-linked immuno sorbent assaysa (Elisa) and electrochemiluminescence assay (ECLIA) in 50 patients with benign ovarian neoplasms and 50 healthy women. The sensitivity and specificity of FS and CA125 in the diagnosis of endometriosis were compared by receiver operator characteristic curve. Results: compared with benign ovarian tumor group (308.61 卤54.39 ng / L) and normal control group (72.12 卤48.97 ng / L), the serum FS level of ovarian type EMT group was 1332.74 卤305.54 ng / L). The serum CA125 level in ovarian type EMT group was significantly higher than that in benign ovarian tumor group (35.21 卤18.32 U / mL) and normal group (18.72 卤6.17 UmL). There was no significant difference in serum CA125 level between the two groups compared with the extraovarian EMT group (46.53 卤27.66 U / mL). Conclusion: the expression of FS in serum of patients with endometriosis is significantly increased, which has important clinical reference value for the diagnosis of early endometriosis, especially for ovarian type endometriosis. It is hopeful to be another serological index for early diagnosis of endometriosis.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R711.71

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