膜联蛋白A1在卵巢型子宫内膜异位症中的表达及意义

发布时间：2018-03-13 07:41

本文选题：子宫内膜异位症　切入点：膜联蛋白　出处：《中国妇产科临床杂志》2017年01期 　论文类型：期刊论文

【摘要】：目的检测膜联蛋白(Annexin)A1在卵巢型子宫内膜异位症中的表达,探讨其在子宫内膜异位症发病机制中的作用。方法提取63例卵巢型子宫内膜异位症(研究组)患者的异位内膜(EM组)及在位内膜(UM组),增殖期36例,分泌期27例;同期获取20例正常内膜为对照组,增殖期11例,分泌期9例。采用免疫组化方法检测Annexin A1在各组内膜组织中的表达;同时检测术后24 h血清肿瘤坏死因子-α(TNF-α)和白介素-6(IL-6)水平。结果 EM组Annexin A1阳性表达明显高于对照组;增殖期与分泌期内膜Annexin A1表达无统计学意义;研究组血清IL-6、TNF-a均值明显高于对照组;重度患者异位内膜Annexin A1阳性表达与血清IL-6、TNF-a增高一致。结论 Annexin A1在卵巢型子宫内膜异位症患者异位内膜高表达,血清IL-6及TNF-a值明显增高,支持内异症免疫炎症学说。
[Abstract]:Objective to detect the expression of Annexin A 1 in ovarian endometriosis. Methods 63 patients with ovarian endometriosis (study group) and UM group (36 cases in proliferative phase and 27 cases in secretory phase) were extracted from 63 patients with ovarian endometriosis (study group) and UM group. Meanwhile, 20 cases of normal endometrium were obtained as control group, 11 cases in proliferative phase and 9 cases in secretory phase. Immunohistochemical method was used to detect the expression of Annexin A1 in the endometrium of each group. Serum levels of TNF- 伪 and IL-6) were measured 24 hours after operation. Results the positive expression of Annexin A1 in EM group was significantly higher than that in control group, but there was no significant difference in the expression of Annexin A1 between proliferative phase and secretory phase. The positive expression of Annexin A1 in patients with severe ectopic endometrium was consistent with that in patients with endometriosis. Conclusion the expression of Annexin A1 in patients with ovarian endometriosis is higher than that in patients with ovarian endometriosis, and the levels of serum IL-6 and TNF-a are higher than those in patients with ovarian endometriosis. To support the theory of immune inflammation in endometriosis.
【作者单位】：首都医科大学附属北京潞河医院妇产科;北京丰台医院妇产科;首都医科大学附属北京朝阳医院妇产科;

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