卵巢浆液性腺癌术后组织中纤毛内转运蛋白20、上皮型和P型钙黏素表达及相关性

发布时间：2018-03-13 07:46

本文选题：卵巢　切入点：浆液性腺癌　出处：《中国老年学杂志》2015年16期 　论文类型：期刊论文

【摘要】：目的检测卵巢浆液性腺癌中纤毛内转运蛋白(IFT)20、上皮型钙黏素(E-cadherin)和P型钙黏素(P-cadherin)的表达,分析其关系。方法 58例卵巢浆液性腺癌患者临床资料及术后标本作为观察组,40例卵巢交界性浆液性肿瘤术后标本作为对照组,40例卵巢良性浆性液囊腺瘤术后标本作为正常对照组。3组中IFT20、E-cadherin和P-cadherin的表达应用免疫组化方法检测。结果 3组中IFT20、E-cadherin和P-cadherin表达的阳性率差别均有统计学意义。观察组中IFT20、E-cadherin和P-cadherin表达的阳性率与肿瘤的最大径、腹水或腹腔冲洗液中癌细胞、累及对侧卵巢和Ki67的表达密切相关。相关性分析显示观察组中IFT20和E-cadherin、IFT20和P-cadherin表达均具有负相关性。结论卵巢浆液性腺癌术后组织中IFT20、E-cadherin和P-cadherin高表达,其不仅对肿瘤形成具有作用,还可以促进肿瘤的进展。
[Abstract]:Objective to detect the expression of ciliated intracellular transporter (IFT20), E-cadherin (E-cadherin) and P-cadherin (P-cadherin) in ovarian serous adenocarcinoma (OSCC). Methods the clinical data of 58 patients with ovarian serous adenoma and the postoperative specimens of 40 cases of ovarian borderline serous tumor were used as the control group and 40 cases of benign ovarian cystadenoma. The expression of IFT20E-cadherin and P-cadherin in normal control group was detected by immunohistochemical method. Results the positive rates of IFT20E-cadherin and P-cadherin in the three groups were significantly different. The positive rate of IFT20E-cadherin and P-cadherin expression was the highest in the observation group. The expression of IFT20, E-cadherin IFT20 and P-cadherin in the control group was positively correlated with the expression of IFT20E-cadherin and P-cadherin in ovarian serous adenocarcinoma after operation. Conclusion the expression of IFT20E-cadherin and P-cadherin in ovarian serous adenocarcinoma is significantly higher than that in control group. It can not only play a role in tumor formation, but also promote the progress of tumor.
【作者单位】：青海红十字医院妇三科;
【分类号】：R737.31

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