孕中期唐氏产前筛查及诊断的临床价值分析

发布时间：2018-03-13 20:36

  本文选题：唐氏筛查　切入点：染色体异常　出处：《广东医学》2017年S2期 　论文类型：期刊论文

【摘要】：目的探讨孕中期唐氏筛查对检出胎儿染色体异常的预测效果。方法对收治的26 841例孕中期(15~20+6周)孕妇进行唐氏筛查,并对筛查阳性孕妇进行羊水细胞染色体分析核型诊断,整合资料进行统计分析与数据挖掘。结果参与唐氏筛查的26 841例孕妇中,筛查阳性率随着年龄的递增而升高(趋势X~2=612.53,P0.001),≥35岁阳性率最高,有1 306例,占26.90%;680例参与核型诊断的孕妇中,检出染色体异常者40例,其中唐氏患儿15例,35岁人群孕唐氏儿11例,占73.33%,≥35岁人群孕唐氏儿4例,占26.67%,差异无统计学意义(X~2=0.16,P=0.690.05)。唐氏筛查对其它染色体异常也有提示作用,经logistic回归分析,年龄和lghCG_MoM是患唐氏综合征的危险因素,lg AFP_MoM和LgμE3_MoM是保护因素。不同地域唐氏筛查中位数参数不同。结论各年龄组孕妇均应重视唐氏综合征的筛查与预防,我国目前应坚持以血清学筛查为基础,以无创DNA检测为补充的筛查策略,各地区应建立自己的中位数系统以保证和提升筛查的效率。
[Abstract]:Objective to investigate the predictive effect of Down's screening in the second trimester of pregnancy for the detection of fetal chromosomal abnormalities. Methods 26 841 pregnant women with fetal chromosomal abnormalities were screened during the second trimester of pregnancy, and the karyotypes of amniotic fluid were diagnosed by chromosome analysis of amniotic fluid in 26 841 pregnant women. Results among 26 841 pregnant women who participated in Down's screening, the positive rate of screening increased with the increase of age. Of 680 pregnant women who participated in karyotype diagnosis, 40 cases were detected chromosomal abnormalities. Among them, 15 cases of Down's children were pregnant with the age of 35 years, 11 cases (73.33%) were pregnant, and 4 cases were pregnant women of 鈮，

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