孕妇血清维生素D水平与妊娠结局的相关性研究

发布时间：2018-03-14 10:17

本文选题：-羟维生素D　切入点：妊娠期　出处：《重庆医学》2016年07期 　论文类型：期刊论文

【摘要】：目的探讨妊娠中晚期孕妇血清25羟维生素D[25(OH)D]营养状态对妊娠结局的影响。方法收集中晚期孕妇143例行问卷调查了解生活习惯。应用高效液相色谱-串联质谱法检测血清25(OH)D,根据血清25(OH)D水平将受试者分为维生素D充足组(n=32)、欠当组(n=49)、不足组(n=51)及缺乏组(n=11)。采用回顾性分析的方法,对孕妇的妊娠结局进行跟踪随访。结果 (1)妊娠中晚期孕妇血清25(OH)D平均值为(22.49±9.51)ng/mL。(2)流产率在充足组、欠当组、不足组、缺乏组分别为3.1%(1/32)、2.0%(1/49)、11.8%(6/51)、36.4%(4/11),胎儿窘迫发生率3.1%(1/32)、8.2%(4/49)、11.8%(6/51)、36.4%(4/11)。维生素D缺乏组流产、胎儿窘迫发生率高于其余各组,差异有统计学意义(P0.05)。(3)各组细菌性阴道病发生率为0(0/32)、4.1%(2/49)、13.7%(7/51)、27.3%(3/11),维生素D缺乏组、不足组细菌性阴道病发生率高于其余各组,差异有统计学意义(P0.05)。(4)各组孕妇妊娠周期为(39.48±1.44)、(39.00±1.70)、(38.09±2.01)、(37.29±0.49)周,维生素D不足组、缺乏组孕周较充足组、欠当组明显缩短,差异有统计学意义(P0.05)。结论妊娠中晚期维生素D缺乏可增加流产、胎儿窘迫、细菌性阴道病的发生率,并显著缩短妊娠周期。
[Abstract]:Objective to investigate the effect of serum 25 hydroxyvitamin D nutritional status on pregnancy outcome in pregnant women in middle and late pregnancy. Methods 143 cases of pregnant women in middle and late pregnancy were investigated with questionnaire to find out their living habits. High performance liquid chromatography-tandem mass spectrometry (HPLC / MS) was used to detect the outcome of pregnancy. The subjects were divided into two groups: vitamin D adequate group (n = 32), inadequate group (n = 49), deficiency group (n ~ (51)) and deficiency group (n ~ (11)). Follow up the pregnancy outcome of pregnant women. Results 1) the average value of serum 25 OHH / D was 22.49 卤9.51ng / mL 路L ~ (-2)) abortion rate in the adequate group, the poor group, the deficient group, and the lack group was 3.1-1 / 1.32 / 2.0and 1 / 49.11.86.46.41.The incidence of fetal distress was 3.32% / 8.2ng / 449 / 41.The incidence rate of fetal distress was 3.32% / 8.2ng / ml / 449 / 11 / 46.411 / .Vitamin D deficiency group had miscarriage. The incidence of fetal distress was higher than that of the other groups, and the difference was statistically significant (P 0.05). The incidence of bacterial vaginosis in each group was 0 / 32 / 4.10.The incidence of bacterial vaginosis in the deficient group was higher than that in the other groups, and the incidence of bacterial vaginosis was higher in the group of vitamin D deficiency than in the other groups, and the incidence of bacterial vaginosis was higher in the group of vitamin D deficiency than in the other groups. The pregnancy cycle of pregnant women in each group was 39.48 卤1.44, 39.00 卤1.70, 38.09 卤2.01, 37.29 卤0.49) weeks. The group with vitamin D deficiency had more adequate gestational weeks, the group with inadequate gestation was shorter than that with inadequate gestation, the difference had statistical significance (P0.050.Conclusion Vitamin D deficiency in middle and late pregnancy can increase abortion. Fetal distress, bacterial vaginosis incidence, and significantly shortened pregnancy cycle.
【作者单位】：贵州省贵阳市第二人民医院内分泌代谢科;
【基金】：贵阳市科技与民生计划项目([2013103]3号)
【分类号】：R714.2

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