环吡酮胺治疗外阴阴道假丝酵母菌病的随机对照研究

发布时间：2018-03-14 11:06

本文选题：外阴阴道假丝酵母菌病　切入点：环吡酮胺　出处：《第二军医大学学报》2015年11期 　论文类型：期刊论文

【摘要】：目的研究环吡酮胺阴道乳膏治疗外阴阴道假丝酵母菌病(vulvovaginal candidiasis,VVC)的疗效。方法根据纳入标准和排除标准,于2012年1月至2013年10月共入选VCC患者605例,随机分配进入试验组和对照组。试验组阴道给予环吡酮胺乳膏5g/d(有效成分环吡酮胺0.05g/d),连用7d;对照组阴道给予硝酸咪康唑栓,200mg/d,连用7d。比较两组临床应用效果。结果最终共有586例患者完成试验,两组的均衡性良好。试验组和对照组用药24h内的症状缓解率分别为78.25%(223/285)和41.86%(126/301),差异有统计学意义(P0.01);停药1周后总有效率分别为91.93%(262/285)和85.05%(256/301),差异有统计学意义(P0.01)。试验组204例治愈患者在停药后3、6个月的复发率分别为0.49%(1/204)和3.92%(8/204),而对照组205例治愈患者的相应复发率分别为7.32%(15/205)和14.15%(29/205),两组比较差异有统计学意义(P0.01)。两组不良反应均轻微。结论环吡酮胺阴道乳膏治疗VVC较硝酸咪康唑更为有效,且可明显降低复发率。
[Abstract]:Objective to study the efficacy of cyclopyramide vaginal cream in the treatment of vulvovaginal candidiasis (VVC). Methods from January 2012 to October 2013, a total of 605 patients with VCC were enrolled according to the inclusion and exclusion criteria. They were randomly assigned to the experimental group and the control group. The vaginal administration of cyclopyramidine cream in the test group was 5 g / d (cyclopyramidine 0.05 g / d for 7 days), and the vaginal administration of miconazole nitrate 200 mg / d in the control group was used for 7 days. The results of clinical application were compared between the two groups. A total of 586 patients eventually completed the trial. The remission rates of symptoms in the test group and the control group within 24 hours were 78.25 and 41.86 / 126 / 301, respectively, and the total effective rates were 91.93 / 285) and 85.05 / 256301g, respectively. The difference was statistically significant in 204 cases in the trial group (204 cases). The recurrence rates of cured patients at 3 and 6 months after withdrawal were 0.491 / 204 and 3.92 / 204respectively, while the corresponding recurrence rates of 205 cured patients in the control group were 7.3215 / 205) and 14.1515 / 205 / 205g, respectively. The difference between the two groups was statistically significant (P0.010.Conclusion the adverse reactions of the two groups were mild. Keto vaginal cream is more effective than miconazole nitrate in the treatment of VVC. The recurrence rate was significantly decreased.
【作者单位】：第四军医大学西京医院妇产科;
【分类号】：R711.3

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