多囊卵巢综合征患者结合珠蛋白基因型及血清水平的研究

发布时间：2018-03-14 16:21

本文选题：多囊卵巢综合征　切入点：结合珠蛋白　出处：《上海交通大学学报(医学版)》2017年04期 　论文类型：期刊论文

【摘要】：目的·探讨多囊卵巢综合征(PCOS)患者血清结合珠蛋白(Hp)水平及其与各代谢指标的相关性;探讨PCOS患者Hp基因型和基因频率的分布及其与PCOS之间的关系。方法·病例组选取106例PCOS患者,对照组选取86例无高雄激素血症、月经规律的妇女。酶联免疫吸附测定(ELISA)检测血清Hp水平;聚合酶链反应(PCR)检测Hp基因型和基因频率的分布。结果·PCOS组血清Hp水平显著高于对照组(P=0.000),分析结果表明血清Hp水平变化与体质量指数(BMI)、稳态模型胰岛素抵抗指数(HOMAIR)正相关(均P=0.000);PCOS组Hp2-2(Hp2/Hp2)基因型显著高于对照组(P=0.006),Hp2基因频率明显升高(P=0.002)。结论·PCOS患者血清Hp水平与BMI和HOMA-IR正相关,可能与肥胖和胰岛素抵抗的发生发展有关。携有Hp2-2基因型的人群可能对PCOS有较高的遗传易感性,Hp2等位基因在PCOS中有聚集现象。
[Abstract]:Objective: to investigate the level of serum bound globin (Hp) in patients with polycystic ovary syndrome (PCOS) and its correlation with various metabolic indexes. To investigate the distribution of HP genotype and gene frequency in patients with PCOS and the relationship between HP genotype and PCOS. Methods: 106 PCOS patients were selected in the case group and 86 patients in the control group were selected without hyperandrogenemia. Elisa was used to detect serum HP level in women with regular menstruation. Results: the serum HP level in PCOS group was significantly higher than that in control group. The results showed that serum HP level and body mass index (BMI), insulin resistance index (IR) in steady-state model were significantly higher than those in control group. The genotype of Hp2-2Hp2 / Hp2 in PCOS group was significantly higher than that in control group. Conclusion the serum HP level in patients with PCOS was positively correlated with BMI and HOMA-IR. It may be related to the occurrence and development of obesity and insulin resistance. The population with Hp2-2 genotype may have a higher genetic susceptibility to PCOS and the Hp2 allele may be clustered in PCOS.
【作者单位】：重庆医科大学附属第一医院生殖健康与不孕症专科;
【分类号】：R711.75

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