人乳头瘤病毒E7蛋白检测子宫颈上皮内病变的价值

发布时间：2018-03-16 01:22

本文选题：人乳头瘤病毒　切入点：E蛋白　出处：《中国妇产科临床杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的探讨人乳头瘤病毒(HPV)E7蛋白检测宫颈病变的临床应用价值。方法选取180例高危型HPV阳性妇女,采用免疫细胞化学方法检测宫颈脱落细胞HPV E7蛋白。结果 (1)病理高级别宫颈上皮内病变(HSIL)及浸润癌组HPV E7蛋白阳性率(77.8%,56/72)显著高于低级别宫颈上皮内病变(LSIL)组(52.1%,25/48;P=0.003),病理LSIL组阳性率显著高于宫颈炎组(26.7%,16/60;P=0.007);(2)对于细胞学为ASCUS和LSIL的妇女,HPV E7蛋白诊断HSIL及宫颈癌的灵敏度、特异度、阳性预测值及阴性预测值分别为97.1%、52.1%、58.9%和96.2%;(3)HPV E7蛋白和TCT诊断LSIL及以上病变的灵敏度、特异度、阳性预测值、阴性预测值分别为67.5%vs 51.7%、73.3%vs 58.3%、83.5%vs 71.3%、53.0%vs 37.6%,除特异度外,E7蛋白诊断的价值优于TCT(P0.05)。结论 HPV E7蛋白在检测宫颈病变,尤其是在细胞学轻度异常患者的分流中,具有一定的临床应用价值。
[Abstract]:Objective to investigate the clinical application value of human papillomavirus (HPV) E7 protein in detecting cervical lesions. Methods 180 high-risk HPV positive women were selected. The immunocytochemical method was used to detect the HPV E7 protein in exfoliated cervical cells. Results 1) the positive rate of HPV E7 protein in high grade cervical intraepithelial lesion and invasive carcinoma group was significantly higher than that in low grade cervical intraepithelial lesion group (52.1%, 25%, 48 P, 0.003), and the positive rate of HPV E 7 protein in invasive carcinoma group was significantly higher than that in low grade cervical intraepithelial lesion group. The positive rate of HPVE7 protein in pathological LSIL group was significantly higher than that in cervicitis group. The sensitivity of HPVE7 protein to the diagnosis of HSIL and cervical cancer in women with ASCUS and LSIL cytology was significantly higher than that in cervicitis group. Specificity, positive predictive value and negative predictive value were 97.1% and 96.22HPVE7 protein, respectively. The sensitivity, specificity, positive predictive value of HPVE7 protein and TCT in the diagnosis of LSIL and above lesions were 97.1% and 96.22.2%, respectively. The negative predictive values were 67.5 vs 51.73.3 and 58.3% and 83.5 vs 71.3% vs 71.3% vs 71.3% and 53.0% vs 37.3%, respectively. The diagnostic value of HPV E7 protein was higher than that of TCTP 0.05 in the diagnosis of cervical lesions, especially in the patients with mild abnormal cytology. Conclusion HPV E7 protein is of certain clinical value in the detection of cervical lesions, especially in the shunt of patients with mild cytologic abnormalities.
【作者单位】：南京大学医学院附属鼓楼医院妇产科;南京大学医学院附属鼓楼医院病理科;
【基金】：国家卫计委科教司公益性行业科研专项项目(201502004) 南京市医学科技发展项目(YKK14079)
【分类号】：R737.33

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