陕西省延安地区女性HPV感染及基因分型年龄分布

发布时间：2018-03-17 23:18

  本文选题：人乳头瘤病毒　切入点：基因分型　出处：《中华肿瘤防治杂志》2017年11期 　论文类型：期刊论文

【摘要】：目的宫颈癌的发生发展与人乳头瘤病毒(human papillomavirus,HPV)密切相关,本研究分析陕西省延安地区女性宫颈HPV感染情况及基因亚型年龄分布,为本地区女性宫颈癌防治和HPV感染的分子流行病学研究提供重要依据。方法选择2011-01-01-2015-07-31延安大学附属医院体检(478例)、"两癌"筛查、机会性筛查(2 250例)及就诊(814例)的3 542例女性患者作为研究对象,采用PCR体外扩增和DNA反向点杂交相结合的DNA芯片技术进行HPV基因分型检测。结果 HPV感染率为40.54%(1 436/3 542),其中高危型HPV感染率38.42%(1 361/3 542);低危型HPV感染率3.78%(134/3 542);感染年龄分布以≥61岁年龄组感染率最高,其次是51~60岁年龄组。各年龄组HPV感染率和高危感染率比较差异均有统计学意义,P0.05;低危感染率比较差异无统计学意义,P0.05。按年龄组统计,高危亚型检出频次由高到低排列前3位,≤30岁年龄组为HPV16、HPV58和HPV39,其余各组均为HPV16、HPV58和HPV52。低危感染以HPV6和HPV11为主。单一型别感染占总感染人数的74.72%(1 073/1 436),其中单一高危感染占69.56%(999/1 436),单一低危占5.15%(74/1 436)。多重感染占总感染人数的25.27%(363/1 436),最高检出四重感染。单一感染率、单一高危感染率最高的为41~50岁年龄组,多重高危感染率和高低危混合多重感染率最高的是≥61岁年龄组,各年龄组高低危混合多重感染率比较差异有统计学意义(P0.05),其余感染类型差异均无统计学意义,P0.05。结论陕西省延安地区HPV感染年龄分布以≥61岁年龄组较高,主要亚型为HPV16、HPV58和HPV52,感染类型以单一感染为主,提示HPV亚型的分析对疫苗的研发和宫颈癌的筛查及防治有指导意义。
[Abstract]:Objective the occurrence and development of cervical cancer is closely related to human papillomavirus (HPV). This study analyzed the HPV infection and age distribution of cervical subtype in women in Yan'an area of Shaanxi Province. Methods 478 cases of female cervical cancer and HPV infection in Yanan University affiliated hospital were selected from 2011 to 01-2015-07-31, and "two carcinomas" were screened. 2 250 cases of opportunistic screening and 3 542 cases of female patients (814 cases) were studied. DNA microarray combined with PCR amplification in vitro and reverse dot hybridization of DNA was used to detect the genotyping of HPV. Results the infection rate of HPV was 40.54 and 1 436/3 542, of which the high risk HPV infection rate was 38.42%, the low risk HPV infection rate was 3.78% / 3 542%; the age of infection was 38.42%. The infection rate was highest in the age group 鈮，

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