肿瘤相关因子在卵巢癌中的表达及其与淋巴结转移相关性研究

发布时间：2018-03-19 02:35

本文选题：卵巢癌　切入点：癌抗原　出处：《中国临床药理学杂志》2015年22期 　论文类型：期刊论文

【摘要】：目的探讨癌抗原125、人附睾上皮分泌蛋白及糖类抗原199在卵巢癌中的表达及其与淋巴结转移的相关性。方法将103例上皮性卵巢癌患者分为试验组65例(发生淋巴结转移)和对照组38例(无淋巴结转移)。检测2组患者的血清癌抗原125、人附睾上皮分泌蛋白及糖类抗原199表达水平,并分析淋巴结转移与其相关性。根据贝叶斯定理分析血清癌抗原125、人附睾上皮分泌蛋白及糖类抗原199诊断淋巴结转移的敏感性、特异性及受试者工作特征曲线(ROC)下面积。结果对照组的血清癌抗原125、人附睾上皮分泌蛋白及糖类抗原199中位数分别为223.3 k U·L-1,82.0 pmol·L-1和10.9 U·m L-1;试验组分别为891.0 k U·L-1,238.0 pmol·L-1和16.3 U·m L-1,试验组的上述指标显著高于对照组(P0.05)。癌抗原125判断淋巴结转移的敏感性为73.85%,特异性为73.68%,ROC曲线下面积为0.77;人附睾上皮分泌蛋白判断淋巴结转移的敏感性为80.00%,特异性为60.53%,ROC曲线下面积为0.69;糖类抗原199判断淋巴结转移的敏感性为64.62%,特异性为57.89%,ROC曲线下面积为0.65。结论癌抗原125、人附睾上皮分泌蛋白及糖类抗原199可作为卵巢癌淋巴结转移的血清标志物。
[Abstract]:Objective to investigate the expression of carcinoantigen 125, human epididymal epithelial secretory protein and carbohydrate antigen 199 in ovarian cancer and their correlation with lymph node metastasis. Methods 103 patients with epithelial ovarian cancer were divided into trial group (n = 65) and lymph node metastasis group (n = 65). The levels of serum carcinoantigen 125, human epididymal epithelial secretory protein and carbohydrate antigen 199 were detected in 38 cases of control group (without lymph node metastasis). The sensitivity of serum carcinoantigen 125, human epididymal epithelial secretory protein and carbohydrate antigen 199 in the diagnosis of lymph node metastasis was analyzed. Results the median values of serum carcinoantigen 125, human epididymal epithelial secretory protein and carbohydrate antigen 199in the control group were 223.3 KU 路L -1 and 10.9 U 路m -1, respectively, and those in the experimental group were 891.0 k U 路L -1 and 238.0 pmol 路L -1, respectively. 16.3 U 路ml -1, the above indexes in the trial group were significantly higher than those in the control group (P 0.05). The sensitivity of carcinoantigen 125 in judging lymph node metastasis was 73.85, the specificity was 73.68 and the area under the ROC curve was 0.77, and the sensitivity of human epididymal epithelial secretory protein in judging lymph node metastasis was 80.00. The specificity is 60.53 and the area under the ROC curve is 0.69; the sensitivity of carbohydrate antigen 199 to determine lymph node metastasis is 64.62; the specificity is 57.8910; the area under the ROC curve is 0.65.Conclusion Cancer antigen 125, human epididymal epithelial secretory protein and carbohydrate antigen 199 can be used as ovarian cancer lymphoid. A serum marker for the metastases of the cadaver.
【作者单位】：厦门市第二医院妇产科;
【基金】：福建省教育厅基金资助项目(JA12145)
【分类号】：R737.31

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