HIV感染孕产妇母婴阻断措施效果的Meta分析

发布时间：2018-03-19 04:02

本文选题：艾滋病病毒　切入点：母婴传播　出处：《中国艾滋病性病》2017年09期 　论文类型：期刊论文

【摘要】：目的通过检索国内外相关文献,分析几种针对艾滋病病毒(HIV)感染孕妇常用的预防母婴传播(PMTCT)措施的有效性。方法计算机检索万方数据库、维普期刊资源整合服务平台、CNKI、PubMed、SpringerLink、中国生物医学文献数据库等,检索时限为数据库建库起至2016年5月,查找所有相关文献,并追溯其原始文献及参考文献,经过逐层筛选后,使用Revman 5.2软件进行Meta分析。结果最终纳入15篇随机对照研究(RCT)或高质量对照研究文献,其中7篇文献对比了单一用药与空白对照组,6篇文献对单一用药及三联用药进行了对比,5篇文献将自然分娩与剖宫产进行了对比。Meta分析结果提示:单一抗病毒药物相对未服用抗病毒药物[比值比(OR)=2.71,95%可信区间(CI):2.10~3.49),P0.000 01]、三联用药相对单一用药(OR=2.72,95%CI:1.84~4.02,P0.000 01)及剖宫产相对自然分娩[相对危险度(RR)=1.61,95%CI:1.15~2.25,P=0.005]均能降低感染风险。结论规律的抗病毒治疗及选择剖宫产分娩均能够有效地降低母婴传播率,其中三联用药的效果优于单一用药。合理的抗病毒治疗、安全的分娩方式是阻断HIV母婴传播的重要措施。
[Abstract]:Objective to analyze the effectiveness of several commonly used measures to prevent mother-to-child transmission of HIV (PMTCTT) in pregnant women with HIV infection by searching related literature at home and abroad. CNKI PubMeder Link. China Biomedical Literature Database, etc. The retrieval time limit is from May 2016 to May 2016 to find all relevant documents, and trace their original documents and references. Revman 5.2 software was used for Meta analysis. The results were included in 15 randomized controlled studies or high quality control studies. Among them, 7 articles were compared with 6 articles in the blank control group, and 5 articles compared the natural delivery with cesarean section. The results of Meta-analysis showed that: single antiviral drug was the only antiviral drug. The relative absence of antiviral drugs [the ratio was 2.71g 95% confidence interval], the triple drug was relatively single drug OR2.7295CIW1.844.02P0.00001) and the relative natural delivery of cesarean section [the relative risk was 1.6195 CI: 1.155.2.25P0.005] can reduce the risk of infection. Conclusion the antiviral therapy of regular pattern can reduce the risk of infection. And the choice of cesarean section can effectively reduce the rate of mother-to-child transmission. The effect of triple drug is better than that of single drug. Reasonable antiviral therapy and safe delivery are important measures to block mother-to-child transmission of HIV.
【作者单位】：新疆维吾尔自治区第六人民医院;
【分类号】：R714.251

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