不同栓塞剂对子宫肌瘤动脉栓塞术后疗效的影响

发布时间：2018-03-19 11:23

本文选题：子宫动脉栓塞术　切入点：子宫肌瘤　出处：《中国实用妇科与产科杂志》2015年10期 　论文类型：期刊论文

【摘要】：目的探讨不同种类及规格的栓塞剂对子宫肌瘤动脉栓塞术后疗效的影响。方法选取贵州医科大学第二附属医院、南方医科大学南方医院及广州市第一人民医院1999—2012年因子宫肌瘤使用规格为300~900μm的聚乙烯醇(PVA)、海藻酸钠微球(KMG)及新鲜明胶海绵颗粒(GF)3种栓塞剂行子宫动脉栓塞术(UAE)治疗的296例病例,术前及术后1、3、6个月、1~8年分别观察记录子宫肌瘤体积变化及月经量改变情况。结果 (1)不同种类及规格栓塞剂间UAE术后3年内疗效差异无统计学意义。术后4年以上单一使用PVA或KMG的疗效差异有统计学意义(χ2=4.744,P=0.029)。(2)使用PVA栓塞后加用GF的疗效亦好于单一使用PVA的疗效(χ2=22.342,P0.01),使用KMG栓塞后加用GF的疗效好于单一使用KMG的疗效(χ2=8.750,P=0.003),而均加用GF后,PVA与KMG的疗效差异无统计学意义(χ2=0.076,P=0.782)。(3)使用颗粒直径300~500μm的栓塞剂术后4年以上疗效好于500~700μm(χ2=18.674,P0.01)及700~900μm(χ2=23.963,P0.01)的栓塞剂,而500~700μm的栓塞剂疗效与700~900μm间差异无统计学意义(χ2=2.735,P=0.098)。结论单一使用KMG术后疗效较PVA更好;KMG或PVA与GF联合使用行UAE术后疗效好于单一使用;使用颗粒直径为300~500μm的栓塞剂行UAE术后疗效更佳。
[Abstract]:Objective to investigate the effects of different types and specifications of the embolic agent on the curative effect of myoma of uterus artery embolization. Methods the Second Affiliated Hospital of Guizhou Medical University, Nanfang Hospital of Southern Medical University and Guangzhou No.1 People's Hospital from 1999 to 2012 due to uterine fibroids use specifications for 300~ 900 m polyvinyl alcohol (PVA), sodium alginate (KMG) and gelfoam particles (GF 3) embolization for uterine artery embolization (UAE) treatment of 296 cases, 1,3,6 months before and after surgery, 1~8 were observed and recorded changes and changes of uterine fibroid volume menstrual volume. Results (1) there was no significant difference within 3 years the efficacy of different types and specifications of UAE after embolization the difference was statistically significant. The curative effect of 4 years of single use of PVA or KMG after operation (2=4.744, P=0.029). (2) clinical efficacy of GF is better than single use of PVA and PVA after embolization ( X 2=22.342, P0.01), clinical efficacy of GF is better than single KMG plus KMG after embolization (x 2=8.750, P=0.003), and were treated with GF, there was no significant difference between PVA and KMG effect (x 2=0.076, P=0.782). (3) embolization surgery using the particle diameter of 300~500 m after 4 years of good curative effect on 500~700 m (2=18.674, P0.01) and 700~900 m (2=23.963, P0.01) embolic agent, and there was no significant difference of embolization efficacy and 700~900 m 500~700 between M (x 2=2.735, P=0.098). Conclusion PVA better curative effect than single use of KMG operation after KMG or PVA; and GF UAE combined with postoperative curative effect is better than single use; particle diameter efficacy embolic agent underwent UAE 300~500 m.

【作者单位】：贵州医科大学第二附属医院妇产科;南方医科大学南方医院妇产科;广州市第一人民医院妇产科;
【基金】：科技部十二五国家科技支撑项目(2014BAI05B03) 卫生行业科研专项(201002013)
【分类号】：R737.33

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