广州番禺地区妊娠早期妇女的碘营养与甲状腺功能

发布时间：2018-03-19 11:27

本文选题：妊娠早期　切入点：碘营养　出处：《广东医学》2017年12期 　论文类型：期刊论文

【摘要】：目的研究广州番禺地区妊娠早期妇女碘营养情况与甲状腺功能的变化,为今后是否需广泛开展孕妇尿碘和甲状腺功能监测提供依据。方法选择常住番禺地区的妊娠早期妇女2 794例,测定尿碘浓度(UIC)、血清促甲状腺激素(TSH)、游离甲状腺素(FT4)、甲状腺过氧化物酶抗体(TPOAb)和甲状腺球蛋白抗体(Tg Ab)。结果 2 794例妊娠早期孕妇中,重度碘缺乏5.26%,中度碘缺乏12.67%,轻度碘缺乏20.15%,碘充足39.30%,碘过量22.98%,UIC的中位数为155μg/L。临床甲状腺功能减退和亚临床甲状腺功能减退的患病率为0.93%和7.27%,TPOAb和Tg Ab的阳性率分别为9.62%和10.10%。碘缺乏者和碘过量者与碘充足者比较,TSH升高、甲状腺功能减退患病率、TPOAb阳性率增高,差异有统计学意义(P0.05)。TPOAb阳性率和亚临床甲状腺功能减退(甲减)的患病率与UIC减少和增多呈U型趋势。结论广州番禺地区妊娠早期妇女仍有碘营养异常情况,碘缺乏及碘过量均增加发生亚临床甲状腺功能减退、甲状腺自身抗体阳性概率。应在妊娠早期广泛开展尿碘和甲状腺功能、甲状腺抗体的监测,早期发现、早期干预以保障孕妇和胎儿健康。
[Abstract]:Objective to study the changes of iodine nutrition and thyroid function in women in early pregnancy in Panyu, Guangzhou. Methods 2794 early pregnant women living in Panyu were selected as the basis for monitoring urine iodine and thyroid function of pregnant women. Urinary iodine concentration (UIC), serum thyroid stimulating hormone (TSH), free thyroxine FT4 (FT4), thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TG) were determined. Severe iodine deficiency 5.26, moderate iodine deficiency 12.67, mild iodine deficiency 20.15, iodine abundance 39.30, and iodine excess 22.98 UIC were 155 渭 g / L. The prevalence rates of clinical hypothyroidism and subclinical hypothyroidism were 0.93% and 7.27g, respectively. The levels of TSH in iodine deficiency and iodine excess were higher than those in iodine deficiency. The prevalence of hypothyroidism and the positive rate of TPOAb were increased. The positive rate of P0.05TPOAb and the prevalence of subclinical hypothyroidism (hypothyroidism) showed a U-type trend with the decrease and increase of UIC. Conclusion there are still iodine nutritional abnormalities in early pregnancy women in Panyu, Guangzhou. Iodine deficiency and iodine excess increase the incidence of subclinical hypothyroidism and positive rate of thyroid autoantibodies. Urine iodine and thyroid function should be widely carried out in early pregnancy. Early intervention to protect the health of pregnant women and fetuses.
【作者单位】：广东省妇幼保健院内科;
【分类号】：R715.3

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