子痫前期复发对临床结局影响的研究

发布时间：2018-03-22 09:46

本文选题：子痫前期　切入点：复发　出处：《中国妇产科临床杂志》2015年05期 　论文类型：期刊论文

【摘要】：目的探讨子痫前期复发对妊娠结局的影响。方法回顾分析2009年1月至2014年3月在北京大学第三医院住院并分娩的有过子痫前期病史的临床观察病例资料82例,按照此次妊娠有无子痫前期复发分为复发子痫前期组(RPE组)37例和未复发子痫前期组45例(NRPE组),与同期无子痫前期病史此次妊娠初发子痫前期的病例90例(PPE组)进行比较,分析临床结局差异。结果 RPE组合并内科疾病者比例、合并慢性高血压者比例均明显高于NRPE组及PPE组(P0.001、0.001);RPE组子痫前期诊断孕周和妊娠分娩孕周均明显早于PPE组(P=0.009、0.037);RPE组轻度子痫前期者所占比例明显低于PPE组,早发型子痫前期者所占比例、慢性高血压合并子痫前期者所占比例均明显高于PPE组(P=0.015、0.004、0.001);RPE组新生儿出生体重明显低于PPE组,小于孕龄儿比例、活产儿入住新生儿重症监护病房比例明显高于PPE组(P=0.048、0.034、0.015)。结论复发子痫前期较初发子痫前期有更严重的临床结局,母体存在更多的潜在病理状况。应注重复发子痫前期的防范,最大限度减少疾病复发,改善临床结局。
[Abstract]:Objective to investigate the effect of preeclampsia recurrence on pregnancy outcome. Methods 82 cases with history of pre-eclampsia who were hospitalized and delivered in the third Hospital of Peking University from January 2009 to March 2014 were retrospectively analyzed. According to whether preeclampsia recurred in this pregnancy, there were 37 cases of recurrent preeclampsia in RPE group and 45 cases in non-recurrent preeclampsia group, compared with 90 cases of preeclampsia with no history of preeclampsia in the same period. Results the proportion of patients with RPE combined with internal medical diseases was analyzed. The proportion of patients with chronic hypertension was significantly higher than that of NRPE group and PPE group. The proportion of mild preeclampsia in PPE group was significantly earlier than that in PPE group, and the proportion of early onset preeclampsia group was significantly lower than that in PPE group. The proportion of patients with chronic hypertension complicated with preeclampsia was significantly higher than that of PPE group (P 0.015 0. 004). The birth weight of newborns in PPE group was significantly lower than that in PPE group, and the proportion of pregnant infants was lower than that in PPE group. The proportion of live infants admitted to neonatal intensive care unit was significantly higher than that of PPE group. Conclusion recurrent preeclampsia has more severe clinical outcome than that of primary preeclampsia, and there are more potential pathological conditions in mother body, and attention should be paid to the prevention of recurrent preeclampsia. Minimize the recurrence of disease and improve the clinical outcome.
【作者单位】：北京大学第三医院妇产科;
【基金】：国家自然科学基金(81370723) 北京市自然科学基金(7132215)
【分类号】：R714.244

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