妊娠期大气细颗粒物的暴露与胎儿生长发育相关性的meta分析

发布时间：2018-03-22 12:16

本文选题：大气细颗粒物　切入点：母亲暴露　出处：《重庆医科大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:以胎儿生长受限(FGR)、小于胎龄儿(SGA)、低体质量儿(L BW)为主要观察指标,探究妊娠期孕妇接触大气细颗粒物(PM2.5)对胎儿生长发育的影响,评估PM2.5与胎儿生长发育的相关性。方法:采用计算机检索、人工检索相结合的方法在万方数据医药信息系统的医药期刊库、会议论文、学位论文库、维普中文科技期刊全文数据库、中国学术期刊全文数据库(CNKI)、Pub Med/Medline数据库中检索“PM2.5”和“FGR”、“SGA”、“LBW”等关键词,纳入分析所有在2005.01.01-2016.01.31期间发表的PM2.5与胎儿生长发育相关性的流行病学研究。使用Stata12.0进行Meta分析,采用Q检验分析各研究间的异质性,利用固定或随机效应模型计算合并效应值,并对结果进行敏感性分析、发表偏倚的检验与校正。结果:本次Meta分析结果显示,孕早期PM2.5暴露与SGA无关联性(OR=1.029,95%CI:0.979,1.083);整个孕期PM2.5暴露水平每增加10μg/m3,发生FGR/SGA风险增加了3.2%(OR=1.032,95%CI:1.023,1.042);整个妊娠期PM2.5暴露与LBW相关联(OR=1.038,95%CI:1.020,1.056)。结论:在所研究人群中,孕早期PM2.5暴露与SGA无关联性,但是整个妊娠期PM2.5暴露与SGA、LBW相关联。
[Abstract]:Objective: to investigate the effect of exposure to atmospheric fine particulate matter (PM2.5) on fetal growth and development in pregnant women with fetal growth restriction (FGRG), small gestational age (SGA) and low body mass (LBW). To evaluate the correlation between PM2.5 and fetal growth and development. Methods: the methods of computer search and artificial retrieval were used in the database of medical journals, conference papers and degree papers of Wanfang data Medical Information system. The full text database of Chinese scientific and technological journals in Weipu, the full text database of Chinese academic journals, and the key words "PM2.5" and "FGR", "SGA", "LBW", etc., are searched in the database of "PM2.5" and "FGR", "SGA", "LBW" and so on. All epidemiological studies on the correlation between PM2.5 and fetal growth and development published between January 31, 2005.01.01-2016.01.31 were included. Stata12.0 was used for Meta analysis, Q test was used to analyze the heterogeneity of each study, and fixed or random effect models were used to calculate the combined effects. Sensitivity analysis, bias test and correction of the results were carried out. Results: the results of this Meta analysis showed that, There was no correlation between PM2.5 exposure and SGA in the first trimester of pregnancy. For every 10 渭 g / m ~ 3 increase in the level of PM2.5 exposure during pregnancy, the risk of occurrence of FGR/SGA increased by 3.22% 1.032% 95% CI: 1.02323 + 1.042%; PM2.5 exposure was associated with LBW throughout pregnancy. Conclusion: in the study population, early PM2.5 exposure was not associated with SGA. But PM2.5 exposure throughout pregnancy was associated with SGA LBW.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R714.5

【相似文献】