循环肿瘤细胞对卵巢癌预后预测价值的meta分析

发布时间：2018-03-23 03:27

本文选题：卵巢癌　切入点：循环肿瘤细胞　出处：《重庆医科大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：近年来有研究证实卵巢癌患者外周血或者骨髓中存在循环肿瘤细胞（circulating tumor cell, CTC）提示预后不良，但也有研究提示CTC存在与患者预后无关。本文的目的在于通过系统评价的方式来评价CTC与卵巢癌预后的关系。方法：计算机检索Pubmed、Embase、The Cochrane library、CNKI（中国知网）中关于循环肿瘤细胞与卵巢癌预后相关的文章。各数据库均从建库直至2014年2月。以纽卡斯尔-渥太华量（Newcastle-OttawaScale, NOS）评价纳入文献质量。风险比（HR）及关联95%可信区间（95%CI）被用来计算合并效应量。采用stata12.0软件进行meta分析。结果：共纳入8篇文献，共1184例患者，CTC阳性率25.21%(CI,12%-60.6%)。分别按照外周血及骨髓样本计算效应量。在外周血标本中，检测到CTC的卵巢癌患者整体生存期及无进展生存期均明显短于未检测到CTC的患者(HR=2.09; CI:1.13,3.88; p=0.019和HR=1.72; CI:1.32,2.25; p0.0001)。在骨髓标本中，检测到CTC的卵巢癌患者整体生存期及无进展生存期亦明显短于未检测到CTC的患者(HR=1.61; CI:1.27,2.04; p0.0001和HR=1.44; CI:1.15,1.80; p0.0001)。本文同时分析CTC检测与卵巢癌FIGO分期与GRADE分级的关系，结果未提示两者之间有明确关联。结论：本研究显示，循环系统中存在CTC的卵巢癌患者，，整体生存期及无进展生存期均短于CTC阴性的患者，说明CTC与卵巢癌预后有密切关系。CTC可能成为卵巢癌预后评估的一种新的标志物，将来可能对卵巢癌治疗方案的选择提供指导意义。
[Abstract]:Objective: in recent years, some studies have proved that circulating tumor cells exist in peripheral blood or bone marrow of patients with ovarian cancer, suggesting poor prognosis. However, some studies have shown that the existence of CTC has nothing to do with the prognosis of patients. The purpose of this paper is to evaluate the relationship between CTC and prognosis of ovarian cancer through systematic evaluation. Methods: a computer-based search for articles on circulating tumor cells and prognosis of ovarian cancer in Pubmedmedus Embase the Cochrane libraryn CNKI.Each database was conducted from the establishment of the database to February 2014. The evaluation of Newcastle Ottawa Newcastle-Ottawa scale (NOSs) was included in the paper. Quality. Risk ratio (HRR) and correlation 95% CI (95% CI) were used to calculate the combined effect. Meta analysis was performed with stata12.0 software. Results: a total of 1184 patients were included in 8 articles. The positive rate of CTC in 1184 patients was 25.21. The positive rate of CTC was 25. 21% and 12%-60.6% respectively. The effective amount was calculated according to the peripheral blood and bone marrow samples, respectively, in the peripheral blood samples. The overall survival and progression-free survival of ovarian cancer patients with CTC were significantly shorter than that of patients without CTC. In bone marrow specimens, CI: 1.133.88, Pi 0.019 and HR1.72, CI: 1.32, 2.25; p0.0001. The overall survival and progression free survival of ovarian cancer patients with CTC were also significantly shorter than those without CTC. The relationship between CTC detection and FIGO staging and GRADE grading of ovarian cancer was also analyzed. The results did not suggest a clear correlation between the two. Conclusion: the overall survival and progression free survival of ovarian cancer patients with CTC in the circulatory system were shorter than those with negative CTC. The results suggest that CTC is closely related to the prognosis of ovarian cancer. CTC may be a new marker for prognosis evaluation of ovarian cancer, and may provide guidance for the choice of ovarian cancer therapy in the future.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R737.31

【共引文献】