红核妇洁洗液治疗单纯性外阴阴道假丝酵母菌病的随机对照研究

发布时间：2018-03-23 04:34

本文选题：单纯性外阴阴道假丝酵母菌病　切入点：红核妇洁洗液　出处：《现代妇产科进展》2017年06期 　论文类型：期刊论文

【摘要】：目的:评价红核妇洁洗液治疗单纯性外阴阴道假丝酵母菌病(VVC)的有效性和安全性。方法:2014年6月至2016年6月在复旦大学附属妇产科医院门诊募集单纯性VVC患者,随机分为研究组(红核妇洁洗液组)和对照组(硝酸咪康唑软胶囊组),分别在治疗前和治疗结束后1~2周、4周、8周进行真菌检测、瘙痒评价、VVC评分、BV五项检测及安全性评估。结果:治疗后1~2周,研究组和对照组的瘙痒阳性率、真菌阳性率、VVC评分均呈显著下降趋势,两组比较无显著差异。两组治疗后4周与基线相比,p H值、唾液酸苷酶、白细胞脂酶、脯氨酸氨基肽酶阳性率显著下降,但两组无显著差异。治疗后8周,研究组的白细胞脂酶阳性率、VVC评分显著低于对照组。两组患者在治疗前后血常规、生化指标、心电图等无显著差异,无明显不良反应。结论:红核妇洁洗液治疗单纯性VVC有效、安全,在临床上值得进一步应用。
[Abstract]:Objective: to evaluate the efficacy and safety of Hongxufujie lotion in the treatment of simple vulvovaginal candidiasis. Methods: from June 2014 to June 2016, simple VVC patients were recruited from outpatient clinic of Department of Gynecology and Obstetrics Hospital of Fudan University. They were randomly divided into study group (Hongxufujie lotion group) and control group (miconazole nitrate soft capsule group). Results: the positive rate of pruritus and the positive rate of fungi in the study group and the control group were significantly decreased 2 weeks after treatment. The positive rates of sialidase, leucocyte lipase, proline aminopeptidase in the two groups decreased significantly 4 weeks after treatment, but there was no significant difference between the two groups at the 4th week after treatment, compared with the baseline, the positive rates of sialidase, leucocyte lipase and proline aminopeptidase were not significantly different between the two groups. The positive rate of leukocyte lipase in the study group was significantly lower than that in the control group. There was no significant difference in blood routine examination, biochemical index, electrocardiogram between the two groups before and after treatment, and no significant adverse reactions. Conclusion: Hongxufujie lotion is effective in the treatment of simple VVC. It is safe and worthy of further application in clinic.
【作者单位】：复旦大学附属妇产科医院宫颈疾病诊疗中心上海市生殖内分泌重点实验室;复旦大学附属妇产科医院妇科;
【分类号】：R711.31

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