PAX8在卵巢肿瘤中的表达及临床意义

发布时间：2018-03-23 19:04

本文选题：PAX　切入点：卵巢癌　出处：《现代妇产科进展》2015年10期

【摘要】：目的:探讨卵巢良恶性肿瘤病灶中PAX8的表达情况和临床意义。方法:免疫组化法检测60例原发性上皮性卵巢癌、20例卵巢良性肿瘤和10例转移性卵巢癌病灶中PAX8表达,分析PAX8表达与患者临床病理特征、预后的关系。结果:免疫组化染色显示,原发性上皮性卵巢癌、卵巢良性肿瘤中PAX8表达阳性率分别为92%和85%,两组比较差异无统计意义(P=0.761);转移性卵巢癌组织均不表达PAX8,与原发性上皮性卵巢癌比较差异有统计学意义(P0.001)。卵巢癌原发病灶中PAX8表达强度与癌细胞分化程度(P=0.033)、FIGO分期(P=0.003)有关,而与病理类型无关(P=0.871)。生存分析发现,卵巢癌患者中PAX8低表达组的术后生存时间明显优于PAX8高表达组(P=0.009)。结论:与转移性卵巢癌相比,PAX8可特异性表达于原发性上皮性卵巢癌病灶中,且表达程度与癌细胞分化程度和FIGO分期有关。PAX8高表达的卵巢癌患者预后较差。PAX8对判断卵巢癌的来源及预后有重要意义。
[Abstract]:Objective: to investigate the expression of PAX8 in benign and malignant ovarian tumors and its clinical significance. Methods: immunohistochemical method was used to detect the expression of PAX8 in 20 cases of benign ovarian tumors and 10 cases of metastatic ovarian carcinoma. To analyze the relationship between PAX8 expression and clinicopathological features and prognosis. Results: immunohistochemical staining showed that primary epithelial ovarian carcinoma, The positive rates of PAX8 expression in benign ovarian tumors were 92% and 85%, respectively. There was no statistical significance between the two groups, but there was no expression of PAX8 in metastatic ovarian cancer tissues, but there was significant difference between metastatic ovarian cancer and primary epithelial ovarian carcinoma (P 0.001). The intensity of PAX8 expression was related to the degree of differentiation of cancer cells, P0. 033 and Figo staging (P0. 003). Survival analysis showed that the survival time of PAX8 low expression group was significantly longer than that of PAX8 high expression group. Conclusion: compared with metastatic ovarian carcinoma, pPAX8 can be specifically expressed in primary epithelial ovarian carcinoma. The prognosis of ovarian cancer patients with high expression of PAX8 was related to the differentiation of cancer cells and the FIGO stage. PAX8 was of great significance in judging the origin and prognosis of ovarian cancer.
【作者单位】：上海交通大学医学院附属第三人民医院妇产科;上海交通大学医学院附属第三人民医院病理科;同济大学医学院附属杨浦医院妇产科;
【分类号】：R737.31

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