达因-35对不同类型多囊卵巢综合征的疗效分析

发布时间：2018-03-24 10:03

本文选题：达因-　切入点：多囊卵巢综合征(PCOS)　出处：《生殖与避孕》2015年02期

【摘要】：目的:探讨达因-35对不同类型多囊卵巢综合征(PCOS)血清激素及窦卵泡数等的影响。方法:将138例PCOS患者按鹿特丹标准进行分型,选择同期无高雄激素血症及月经紊乱的输卵管性不孕患者78例作为对照组。测定血清生殖激素及空腹胰岛素(FINS)等水平,盆腔超声检测卵巢体积及窦卵泡计数,经达因-35治疗3个周期后观察上述指标变化,评价达因-35对不同类型PCOS的治疗效果。结果:A型[无排卵(O/A)+高雄激素(HA)+卵巢多囊(PCO)]、B型(O/A+PCO)、C型(HA+O/A)和D型(HA+PCO)分别为43例、73例、15例和7例。A型、C型和D型总睾酮(TT)和硫酸脱氢表雄酮(DHEAS)水平高于对照组,各型LH、LH/FSH、FINS及胰岛素评价指数(HOMA-IR)高于对照组,差异均有统计学意义(P0.05)。A型、B型和D型窦卵泡数多于C型及对照组,差异有统计学意义(P0.05)。达因-35治疗3个周期后:A型、C型和D型血清TT降低,差异有统计学意义(P0.05);DHEAS水平有所降低,但差异无统计学意义(P0.05);各型PCOS血清LH和LH/FSH下降,窦卵泡数减少,差异均有统计学意义(P0.01)。结论:华中地区PCOS临床表现以A型和B型多见,达因-35治疗3个周期可明显降低不同类型血清雄激素水平、血清LH水平和LH/FSH比值,减少窦卵泡数。
[Abstract]:Objective: to investigate the effects of dyne-35 on serum hormones and antral follicle count in patients with different types of polycystic ovary syndrome (PCOS). Methods: 138 patients with PCOS were classified according to Rotterdam standard. 78 cases of tubal infertility without hyperandrogenemia and menstrual disorder were selected as control group. Serum reproductive hormone and fasting insulin FINS were measured. Ovarian volume and antral follicle count were measured by pelvic ultrasound. The changes of the above indexes were observed after 3 cycles of treatment with dyne-35. To evaluate the therapeutic effect of Dain-35 on different types of PCOS. Results in 43 cases, 73 cases (15 cases) and 7 cases (.A type C and D type of total testosterone) were treated with type A (O- / A), ovarian polycystic (PCOA), type B (Or / A PCO-C), type C (HA / O / A) and type D (HA / PCO-C), respectively (43 cases, 73 cases, 15 cases, 7 cases, type .A, type C, and type D, total testosterone, TTT), respectively (n = 43, 73 cases, 15 cases and 7 cases, respectively). The levels of DHEASs and dehydroepiandrosterone sulfate were higher than those in the control group. The FSH / FSHFINS and insulin evaluation index (HOMA-IRR) of all types of LHN were significantly higher than those of the control group, and the number of follicles of type B and D were significantly higher than those of type C and control group. After 3 cycles of treatment, the serum TT of type C and D was decreased, but the level of DHEAS was decreased, but there was no significant difference in serum LH and LH/FSH, and the number of antral follicles in all types of PCOS was decreased, and the number of antral follicles was decreased. Conclusion: type A and B are the most common clinical manifestations of PCOS in central China. The levels of serum androgen, serum LH and LH/FSH, and the number of antral follicles were significantly decreased after 3 cycles of treatment with Dain-35.
【作者单位】：武汉市第一医院妇产科;
【基金】：武汉市科技局基金支助项目,项目号:201306230101 0815
【分类号】：R711.75

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