瘦素与可溶性瘦素受体妊娠期变化及作为妊娠期糖尿病早期筛查指标的探索

发布时间：2018-03-26 06:39

本文选题：瘦素　切入点：可溶性瘦素受体　出处：《医学研究生学报》2017年04期

【摘要】：瘦素参与整个妊娠过程,可溶性瘦素受体与代谢综合征、2型糖尿病有着密切关系。瘦素可通过不同的信号转导途径,与胰岛素进行双向调节,共同影响妊娠期糖尿病母体糖代谢和脂质代谢过程,可溶性瘦素受体通过调节瘦素的可利用率和浓度,增加瘦素敏感性,间接参与机体的内分泌代谢过程。文章就瘦素及可溶性瘦素受体在妊娠期的变化及作为妊娠期糖尿病早期筛查指标的可行性进行综述。
[Abstract]:In the whole process of pregnancy, leptin, soluble leptin receptor and metabolic syndrome, type 2 diabetes has a close relationship. Leptin through different signal transduction pathways to regulate and insulin, common effect metabolism and lipid metabolism of diabetic pregnancy maternal glucose, soluble leptin receptor by regulating leptin availability and increased concentration. Leptin sensitivity, indirectly involved in endocrine and metabolic processes. The leptin and soluble leptin receptor in pregnancy induced changes in gestational diabetes mellitus and feasibility as early screening index for review.

【作者单位】：厦门大学附属成功医院内分泌科;
【基金】：厦门市科技计划项目(3502z20144040)
【分类号】：R714.256

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