乳杆菌制剂与抗真菌药物联合及序贯应用治疗重度外阴阴道假丝酵母菌病疗效研究

发布时间：2018-03-26 15:05

本文选题：重度外阴阴道假丝酵母菌病　切入点：乳杆菌制剂　出处：《中国实用妇科与产科杂志》2017年03期

【摘要】：目的探讨阴道乳杆菌活菌制剂定君生与抗真菌药物联合及序贯应用治疗重度外阴阴道假丝酵母菌病(VVC)的有效性及复发情况。方法选取北京大学第一医院2015年10月至2016年1月收治的125例重度VVC患者,采用随机数字表法分为3组,即联合组(46例)、序贯组(39例)、单纯用药组(40例),其中联合组为定君生与氟康唑同时联合用药,序贯组为采用氟康唑先行治疗随后序贯应用定君生,单纯用药组仅应用氟康唑治疗。3组均在治疗开始后第14~21天进行第1次复查,第28~35天进行第2次复查,观察两次复查后的有效率及复发率。结果第1次复查时联合组、序贯组、单纯用药组有效率分别为79.1%、83.3%、42.5%,联合组与序贯组差异无统计学意义,与单纯用药组差异有统计学意义(P0.05);第2次复查时有效率分别为75.6%、59.0%、27.5%,联合组与其他两组比较差异有统计学意义(P0.05);复发率为0、0、12.5%,3组间差异有统计学意义(P0.05)。结论乳杆菌制剂与氟康唑联合及序贯用药治疗重度VVC均可达到更高的有效率并减低复发率,联合用药效果更佳。
[Abstract]:Objective to investigate the efficacy and recurrence of Dingjunsheng and antifungal drugs combined with Lactobacillus vaginalis in the treatment of severe vulvovaginal candidiasis. Methods in October 2015, the first Hospital of Peking University was selected. By January 2016, 125 patients with severe VVC had been treated. The method of random digital table was used to divide into three groups: combined group (n = 46), sequential group (n = 39), single drug group (n = 40). The combined group was treated with fluconazole and fluconazole at the same time, and the sequential group was treated with fluconazole first and then followed by Dingjunsheng. The group treated with fluconazole was treated with fluconazole for the first time on the 21st day after treatment and the second for the 2835th day. The effective rate and recurrence rate were observed. Results the combined group and sequential group were used in the first reexamination. The effective rates were 79.1% and 83.3%, respectively. There was no significant difference between the combined group and the sequential group. The effective rate of the second reexamination was 75.6% and 59.0%, respectively. The difference between the combined group and the other two groups was statistically significant (P 0.05), and the recurrence rate was 0 0 / 12. 5%. Conclusion there is a significant difference among the three groups in the recurrence rate of Lactobacillus preparation. In combination with fluconazole and sequential treatment of severe VVC, the effective rate was higher and the recurrence rate was reduced. The effect of combined medication is better.
【作者单位】：北京大学第一医院;
【分类号】：R711.3

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