氯米芬与来曲唑在多囊卵巢综合征不孕患者中促排卵作用比较

发布时间：2018-03-28 19:30

  本文选题：氯米芬　切入点：来曲唑　出处：《临床军医杂志》2016年04期

【摘要】：目的探讨枸橼酸氯米芬(CC)和来曲唑(LE)在多囊卵巢综合征(PCOS)不孕患者中促排卵的作用。方法选择2014年1月至2015年12月在上海市沃德医疗中心就诊的PCOS不孕患者,随机分为研究组(n=120)和对照组(n=115)。研究组和对照组分别在月经第3天开始应用LE 5 mg和CC 100 mg促排卵,应用5 d后停药,并在至少一个卵泡直径达20 mm时注射10 000 IU的h CG。比较两组患者直径≥14 mm卵泡(优势卵泡)数、直径≥18 mm卵泡数及注射h CG时子宫内膜厚度、促排卵后内分泌指标、周期妊娠率等。结果研究共纳入235例PCOS患者,给予LE促排卵(研究组)的120例中,39例妊娠,周期妊娠率为32.5%,给予CC促排卵(对照组)的115例中,15例妊娠,周期妊娠率为13.0%,两组间比较差异有统计学意义(P0.01)。注射h CG时,对照组子宫内膜厚度(9.4±0.2)mm,高于观察组的(8.0±0.3)mm,差异有统计学意义(P0.05)。促排卵后,对照组组患者的血清雌激素、孕激素和黄体生成素水平均高于观察组,而FSH水平和AMH水平低于观察组,差异均有统计学意义(P0.05)。结论与对照组比较,应用LE对PCOS不孕患者进行促排卵治疗,对子宫内膜影响小,周期妊娠率高。
[Abstract]:Objective to investigate the role of clomiphene citrate (CCC) and letrozolide (letrozolide) in promoting ovulation in infertile patients with polycystic ovary syndrome (PCOS). Methods PCOS infertile patients were selected from January 2014 to December 2015 in Shanghai Ward Medical Center. The study group and the control group were randomly divided into two groups: the control group and the control group were treated with 5 mg of le and 100 mg of CC on the 3rd day of menstruation. At least one follicle with diameter of 20 mm was injected with 10 000 IU of hCG.The number of follicles (dominant follicles) 鈮，

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