晚发型子痫前期患者甲状腺激素及其他部分生化指标的临床分析

发布时间：2018-03-29 08:13

本文选题：妊娠期高血压疾病　切入点：晚发型子痫前期　出处：《延安大学》2017年硕士论文

【摘要】：目的:本研究对晚发型子痫前期患者及正常分娩孕妇的甲状腺激素、凝血功能、血小板功能相关指标及SOD、MAO值进行了比较和分析,探讨参与晚发型子痫前期发病的部分可能因素;并对其肾功能的相关指标进行监测,分析其变化的临床意义。方法:选取138例于2015年10月至2017年2月在我院产科住院分娩的晚发型子痫前期患者作为实验组,其中轻度子痫前期组69例,重度子痫前期组69例;随机选取于我院同期住院分娩、无任何合并症与并发症的70例正常分娩孕妇作为对照组。记录所有孕妇的一般资料;血清TSH、FT4及FT3水平;SOD及MAO值;PT、APTT、TT及FIB值;MPV、PDW及PLT值;s Cr、UA、Cys C及β2-MG的值。采用统计学软件SPSS 22.0对所收集的资料进行分析。结果:1.三组研究对象甲状腺激素指标的比较:子重组TSH值较子轻组、对照组明显升高,FT4、FT3值均明显降低。2.三组研究对象SOD、MAO水平的比较:子重组SOD值较子轻组和对照组均明显降低,且子轻组与对照组比较时SOD值亦明显降低。子重组的MAO值明显低于对照组。3.三组研究对象凝血功能的比较:子轻组PT值较对照组明显减低,TT值明显升高。子重组PT、FIB值均明显低于子轻组和对照组,TT值明显高于子轻组和对照组。子重组的APTT值明显低于子轻组。4.三组研究对象血小板功能相关指标的比较:子重组MPV和PDW值均明显高于子轻组及对照组,而PLT值明显低于子轻组及对照组。5.三组研究对象肾功能指标的比较:子轻组的UA及Cys C值均明显高于对照组。子重组s Cr、UA、Cys C及β2-MG值均明显高于子轻组和对照组。结论:1.晚发型子痫前期的发生可能与孕妇体内TSH水平升高、FT4及FT3水平低下有关。2.晚发型子痫前期的发生可能与机体抗氧化能力减弱或氧化应激激活有关。3.机体凝血功能亢进、血小板消耗可能在晚发型子痫前期的疾病进展过程中起到一定的作用。4.UA及Cys C值能够更加敏感的反映肾功能的损害。若能够联合s CR、UA、Cys C及β2-MG值的改变来衡量肾功能,可以更加敏感的发现早期肾损害。
[Abstract]:Objective: to compare and analyze the thyroid hormones, coagulation function, platelet function and SODU Mao in patients with late onset preeclampsia and normal delivery pregnant women, and to explore some possible factors involved in the onset of late onset preeclampsia. The clinical significance of the changes was analyzed. Methods: 138 patients with late-onset preeclampsia who were delivered in our hospital from October 2015 to February 2017 were selected as experimental group. There were 69 cases of mild preeclampsia group and 69 cases of severe preeclampsia group. Serum TSHT FT 4 and FT3 levels sod and MAO values PTT TT and FIB values of MPVU PDW and PLT C and 尾 2-MG. The collected data were analyzed with the statistical software SPSS 22.0.Results 1.The thyroid hormone indexes of the three groups were compared as follows: (1) the indexes of thyroid hormones in the three groups were compared as follows: (1) the indexes of thyroid hormones in the three groups were compared as follows: (1) the indexes of thyroid hormones in the three groups of subjects were compared as follows:. The TSH value of the group was lower than that of the subgroup. Compared with the light group and the control group, the SOD values of the three groups were significantly lower than those of the light group and the control group, and the level of SOD4 / MAO in the three groups was significantly lower than that in the light group and the control group, and there was no significant difference between the control group and the control group. Compared with the control group, the SOD value of the sub-light group was significantly lower than that of the control group, and the MAO value of the subgroup was significantly lower than that of the control group .3.The coagulation function of the three groups was compared. The PT value of the sub-light group was significantly lower than that of the control group, and the TT value of the subgroup was significantly increased. The APTT value of the subgroup was significantly lower than that of the light group and control group, and the APTT value of the subgroup was significantly lower than that of the subgroup .4.Compared with the three groups, the MPV and PDW values of the three groups were all clear. It was significantly higher than that in the light group and the control group. However, the PLT value was significantly lower than that in the subgroup and the control group. The comparison of renal function indexes among the three groups: the UA and Cys C values of the subgroup were significantly higher than those of the control group, and the values of the subrecombinant sCRA UACys C and 尾 2-MG were significantly higher than those of the subgroup and the control group. Conclusion 1. The occurrence of late-onset preeclampsia may be related to the increase of TSH level and the low levels of FT4 and FT3 in pregnant women. The occurrence of late-onset preeclampsia may be related to the decrease of antioxidant capacity or the activation of oxidative stress. Platelet consumption may play a role in the progression of late onset preeclampsia. 4. The values of UA and Cys C can more sensitively reflect the impairment of renal function. Early renal damage can be detected more sensitively.
【学位授予单位】：延安大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R714.244

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