超声检查与母体血清学联合检测筛查胎儿先天性心脏病

发布时间：2018-03-30 07:40

  本文选题：先天性心脏病　切入点：颈项透明层厚度　出处：《中国现代医学杂志》2017年13期

【摘要】：目的探讨于孕早期颈项透明层厚度(NT)、三尖瓣反流(TR)与动脉导管(DV)和孕中期母体血清甲胎蛋白(AFP)、游离β绒毛膜促性腺激素(free-β-HCG)检测在筛查胎儿先天性心脏病(CHD)中的意义和作用。方法对2010年12月-2016年2月于该院就诊的单胎孕妇共2 632例,于孕11~14周时进行产前诊断时行超声检查,3项超声检查均异常视为高危;所有孕妇亦于孕15~21周进行母血清标志物AFP和free-β-HCG测定,风险率≥1/270为血清学筛查高危。并对所有孕妇进行随访。对超声检查高危、血清学筛查高危与两者联合筛查均高危结果进行比较。结果分别比较超声检查、血清学检测2种检测结果,差异无统计学意义;联合筛查与超声检查、血清学检测结果比较,差异有统计学意义(P0.05)。结论胎儿NT、TR、DV及母体血清学检测异常提示胎儿存在潜在的CHD的风险,超声检查联合血清学检查能提高CHD的检出率。
[Abstract]:Objective to investigate the clinical significance of detecting the thickness of transparent layer of cervical tract (NTT), tricuspid regurgitation (TRT) and ductus arteriosus (DVV), maternal serum AFP (AFP) and free 尾 chorionic gonadotropin (free- 尾 -HCG) in the screening of fetal congenital heart disease (CHD) in the first trimester of pregnancy. Methods from December 2010 to February 2016, a total of 2,632 single-child pregnant women were admitted to the hospital. At the 14th week of gestation, 3 items of ultrasound examination were regarded as high risk, and the maternal serum markers AFP and free- 尾 -HCG were measured at 1521 weeks of gestation. The risk rate 鈮，

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