氧化再生纤维素防粘连膜在重度宫腔粘连治疗中的作用及其对转化生长因子β1表达的影响

发布时间：2018-04-01 21:21

本文选题：宫腔粘连　切入点：氧化再生纤维素防粘连膜　出处：《现代妇产科进展》2016年01期

【摘要】：目的:探讨转化生长因子β1(TGF-β1)在重度宫腔粘连发生中的作用,氧化再生纤维素防粘连膜(ORC)预防再粘连的作用及其对TGF-β1表达的影响。方法:选择60例重度宫腔粘连的患者,随机分为观察组和对照组(各30例)。观察组术后宫腔内置入宫内节育器(IUD)+ORC,对照组置入IUD。两组人工周期3个月后复查宫腔镜,观察疗效。通过免疫组化法测定子宫内膜组织中TGF-β1表达水平。结果:治疗前,正常组织和粘连组织中TGF-β1表达量分别为3.33±0.73和5.73±1.61,两者比较差异有统计学意义(P0.01)。两组正常内膜及粘连组织中的TGF-β1表达,治疗后均高于治疗前,差异有统计学意义(P0.01)。观察组治疗后粘连组织中TGF-β1表达低于对照组,差异有统计学意义(P0.01)。观察组的治疗总有效率83.33%,对照组为60.00%,差异有统计学意义(P0.05)。再次粘连的病例中,观察组的分度较对照组降低,差异有统计学意义(P0.05)。结论:TGF-β1可能参与重度宫腔粘连的形成,使用ORC能提高治疗有效率,降低再粘连的分度,并能下调TGF-β1。
[Abstract]:Objective: to investigate the role of transforming growth factor 尾 1 (TGF- 尾 1) in the occurrence of severe intrauterine adhesions, and the role of oxidized regenerated cellulose (ORC) in preventing readhesion and its effect on the expression of TGF- 尾 1. Methods: sixty patients with severe intrauterine adhesions were selected. They were randomly divided into observation group and control group (30 cases each). The observation group was treated with intrauterine IUD after operation, and the control group with IUD. The two groups were reexamined by hysteroscopy after 3 months of artificial cycle. The expression of TGF- 尾 1 in endometrial tissue was determined by immunohistochemical method. Results: before treatment, The expression of TGF- 尾 1 in normal tissue and adhesive tissue were 3.33 卤0.73 and 5.73 卤1.61respectively, the difference was statistically significant (P 0.01). The expression of TGF- 尾 1 in normal endometrium and adhesive tissue was higher than that before treatment. After treatment, the expression of TGF- 尾 1 in adhesions in the observation group was lower than that in the control group, and the difference was statistically significant (P 0.01). The total effective rate of treatment in the observation group was 83.33 and that in the control group was 60.00.The difference was statistically significant (P 0.05). Conclusion: TGF- 尾 1 may be involved in the formation of severe intrauterine adhesions. ORC can increase the effective rate of treatment, reduce the grading of re-adhesions, and down-regulate TGF- 尾 1.
【作者单位】：南方医科大学附属深圳市妇幼保健院妇产科;
【基金】：深圳市医疗卫生类科技项目(No:201303082)
【分类号】：R711.74

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