子宫内膜癌组织Septin-9表达变化及其意义

发布时间：2018-04-02 00:37

  本文选题：子宫内膜癌　切入点：Septin-　出处：《山东医药》2017年36期

【摘要】：目的探讨子宫内膜癌组织Septin-9 mRNA表达变化及其临床意义。方法选择子宫内膜癌患者120例(子宫内膜癌组)、子宫内膜不典型增生患者63例(不典型增生组)、子宫肌瘤患者70例(子宫肌瘤组),分别取手术切除的子宫内膜癌组织、子宫内膜不典型增生组织、正常子宫内膜组织,采用qRT-PCR法检测各子宫内膜组织Septin-9 mRNA表达。同时分析子宫内膜癌组织Septin-9 mRNA表达与患者临床病理参数及预后的关系。结果子宫内膜癌组、不典型增生组、子宫肌瘤组Septin-9 mRNA相对表达量分别为1.98±0.51、1.64±0.23、1.00±0.00,组间两两比较P均0.05。子宫内膜癌组Septin-9 mRNA表达与淋巴结转移、肌层浸润和FIGO分期有关(P均0.05),与患者年龄、绝经状态、病理类型及病理分级无关(P均0.05)。以子宫内膜癌组Septin-9 mRNA相对表达量的下四分位数为界值,将子宫内膜癌患者分为Septin-9 mRNA低表达者和Septin-9 mRNA高表达者。Septin-9 mRNA高表达者术后5年生存率及总生存时间均低于Septin-9 mRNA低表达者(P均0.05)。结论子宫内膜癌组织Septin-9 mRNA表达升高,其表达变化可能有助于子宫内膜癌诊断、病情评估及预后预测。
[Abstract]:Objective to investigate the expression of Septin-9 mRNA in endometrial carcinoma and its clinical significance. Methods 120 cases of endometrial carcinoma (endometrial carcinoma group), 63 cases of endometrial atypical hyperplasia (atypical hyperplasia group, uterine leiomyoma) were selected. 70 patients (uterine leiomyoma group, respectively, removed endometrial carcinoma tissue, Endometrial atypical hyperplasia, normal endometrial tissue, The expression of Septin-9 mRNA in endometrial tissues was detected by qRT-PCR method. The relationship between the expression of Septin-9 mRNA and the clinicopathological parameters and prognosis of patients with endometrial carcinoma was analyzed. The relative expression of Septin-9 mRNA in uterine leiomyoma group was 1.98 卤0.51t 1.64 卤0.231.00 卤0.000.The expression of Septin-9 mRNA in endometrial carcinoma group was correlated with lymph node metastasis, myometrium infiltration and FIGO stage (P 0.05), and was related to age and menopausal status. There was no correlation between pathological type and pathological grade (P < 0.05). The lower quartile of Septin-9 mRNA expression in endometrial carcinoma group was taken as the boundary value. The 5-year survival rate and total survival time of endometrial carcinoma were lower than those of patients with low expression of Septin-9 mRNA and high expression of Septin-9 mRNA. Conclusion Septin-9 mRNA expression in endometrial carcinoma is higher than that in patients with low expression of Septin-9 mRNA. The changes of its expression may be helpful for diagnosis, evaluation and prognosis prediction of endometrial carcinoma.
【作者单位】： 青海红十字医院;
【分类号】：R737.33
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本文编号：1698039